The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock

dc.contributor.advisorSwingler, George Hen_ZA
dc.contributor.authorHatherill, Marken_ZA
dc.date.accessioned2015-01-05T06:59:17Z
dc.date.available2015-01-05T06:59:17Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (leaves 106-112).en_ZA
dc.description.abstractMeasures of the severity of metabolic acidosis (base excess) and of the severity of the underlying acid-base derangements (levels of lactate, chloride, albumin, and strong ion gap) have been used to differentiate survivors from nonsurvivors in various types of adult critical illness, including states of severe hamodynamic compromise following cardiac surgery on cardiopulmonary bypass (CPB) and in septic shock. prognostic studies of acid-base data for critically ill children in the settings of post-operative cardiogenci shock and septic shock are relatively scarce. It has been suggested that hyperchloraemia migh be a benign phenomenon that should not prompt escalation of therapy. Although it is recognised that hypoalbuminaemia is associated with adverse outcome, and obscrues the extent of underlying metabolic acidosis, the significance of 'unmeasured' anions estimated from the strong ion gap remains controversial. It has been suggested that the admission lactate level is strongly predictive of paediatric intensive care unit (PICU) outcome in both shock states, but it is not known whether calculation of the lactate: pyruvate ratio would add prognostic value in children with either post-operative cardiogenic, or septic shock.en_ZA
dc.identifier.apacitationHatherill, M. (2007). <i>The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/11362en_ZA
dc.identifier.chicagocitationHatherill, Mark. <i>"The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2007. http://hdl.handle.net/11427/11362en_ZA
dc.identifier.citationHatherill, M. 2007. The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hatherill, Mark AB - Measures of the severity of metabolic acidosis (base excess) and of the severity of the underlying acid-base derangements (levels of lactate, chloride, albumin, and strong ion gap) have been used to differentiate survivors from nonsurvivors in various types of adult critical illness, including states of severe hamodynamic compromise following cardiac surgery on cardiopulmonary bypass (CPB) and in septic shock. prognostic studies of acid-base data for critically ill children in the settings of post-operative cardiogenci shock and septic shock are relatively scarce. It has been suggested that hyperchloraemia migh be a benign phenomenon that should not prompt escalation of therapy. Although it is recognised that hypoalbuminaemia is associated with adverse outcome, and obscrues the extent of underlying metabolic acidosis, the significance of 'unmeasured' anions estimated from the strong ion gap remains controversial. It has been suggested that the admission lactate level is strongly predictive of paediatric intensive care unit (PICU) outcome in both shock states, but it is not known whether calculation of the lactate: pyruvate ratio would add prognostic value in children with either post-operative cardiogenic, or septic shock. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock TI - The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock UR - http://hdl.handle.net/11427/11362 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11362
dc.identifier.vancouvercitationHatherill M. The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11362en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSchool of Child and Adolescent Healthen_ZA
dc.titleThe relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shocken_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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