Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary

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dc.contributor.authorGyamfi, Joyce
dc.contributor.authorOjo, Temitope
dc.contributor.authorIwelunmor, Juliet
dc.contributor.authorOgedegbe, Gbenga
dc.contributor.authorRyan, Nessa
dc.contributor.authorDiawara, Amy
dc.contributor.authorNnodu, Obiageli
dc.contributor.authorWonkam, Ambroise
dc.contributor.authorRoyal, Charmaine
dc.contributor.authorPeprah, Emmanuel
dc.date.accessioned2021-10-12T07:05:58Z
dc.date.available2021-10-12T07:05:58Z
dc.date.issued2021-02-17
dc.date.updated2021-02-21T04:27:11Z
dc.description.abstractBackground The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. Main Body We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. Conclusion This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life.en_US
dc.identifier.apacitationGyamfi, J., Ojo, T., Iwelunmor, J., Ogedegbe, G., Ryan, N., Diawara, A., ... Peprah, E. (2021). Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary. <i>Globalization and Health</i>, 17(Article number: 20), http://hdl.handle.net/11427/35180en_ZA
dc.identifier.chicagocitationGyamfi, Joyce, Temitope Ojo, Juliet Iwelunmor, Gbenga Ogedegbe, Nessa Ryan, Amy Diawara, Obiageli Nnodu, Ambroise Wonkam, Charmaine Royal, and Emmanuel Peprah "Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary." <i>Globalization and Health</i> 17, Article number: 20. (2021) http://hdl.handle.net/11427/35180en_ZA
dc.identifier.citationGyamfi, J., Ojo, T., Iwelunmor, J., Ogedegbe, G., Ryan, N., Diawara, A., Nnodu, O. & Wonkam, A. et al. 2021. Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary. <i>Globalization and Health.</i> 17(Article number: 20) http://hdl.handle.net/11427/35180en_ZA
dc.identifier.ris TY - Journal Article AU - Gyamfi, Joyce AU - Ojo, Temitope AU - Iwelunmor, Juliet AU - Ogedegbe, Gbenga AU - Ryan, Nessa AU - Diawara, Amy AU - Nnodu, Obiageli AU - Wonkam, Ambroise AU - Royal, Charmaine AU - Peprah, Emmanuel AB - Background The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. Main Body We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. Conclusion This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life. DA - 2021-02-17 DB - OpenUCT DP - University of Cape Town IS - Article number: 20 J1 - Globalization and Health KW - Global health KW - Implementation science research KW - Sickle cell disease KW - Africa KW - Scale-up LK - https://open.uct.ac.za PY - 2021 T1 - Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary TI - Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary UR - http://hdl.handle.net/11427/35180 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12992-021-00671-x
dc.identifier.urihttp://hdl.handle.net/11427/35180
dc.identifier.vancouvercitationGyamfi J, Ojo T, Iwelunmor J, Ogedegbe G, Ryan N, Diawara A, et al. Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary. Globalization and Health. 2021;17(Article number: 20) http://hdl.handle.net/11427/35180.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDivision of Human Geneticsen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceGlobalization and Healthen_US
dc.source.journalissueArticle number: 20en_US
dc.source.journalvolume17en_US
dc.source.urihttps://globalizationandhealth.biomedcentral.com/
dc.subjectGlobal healthen_US
dc.subjectImplementation science researchen_US
dc.subjectSickle cell diseaseen_US
dc.subjectAfricaen_US
dc.subjectScale-upen_US
dc.titleImplementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentaryen_US
dc.typeJournal Articleen_US
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