The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

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dc.contributor.authorLi, Dongpingen_ZA
dc.contributor.authorDandara, Colleten_ZA
dc.contributor.authorParker, M Iqbalen_ZA
dc.date.accessioned2015-11-11T12:00:54Z
dc.date.available2015-11-11T12:00:54Z
dc.date.issued2010en_ZA
dc.description.abstractBACKGROUND: The Glutathione S-transferases (GSTs) comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study the effects of polymorphisms in these genes on the risk of developing oesophageal squamous cell carcinoma (OSCC) were evaluated in a hospital-based case-control study in two South African population groups. Genetic polymorphisms in GSTs were investigated in 245 patients and 288 controls samples by PCR-RFLP analysis. RESULTS: The GSTP1 341T variant was associated with significantly increased risk of developing OSCC as observed from the odds ratios for the GSTP1 341C/T and GSTP1 341T/T genotypes (OR = 4.98; 95%CI 3.05-8.11 and OR = 10.9; 95%CI 2.43-49.1, respectively) when compared to the homozygous GSTP1 341C/C genotype. The risk for OSCC in the combined GSTP1 341C/T and T/T genotypes was higher in tobacco smokers (OR = 7.51, 95% CI 3.82-14.7), alcohol consumers (OR = 15.3, 95% CI 1.81-12.9) and those using wood or charcoal for cooking and heating (OR = 12.1, 95% CI 3.26-49) when compared to those who did not smoke tobacco, or did not consume alcohol or user other forms of fuel for cooking and heating. Despite the close proximity of the two GSTP1 SNPs (313A>G and 341C>T), they were not in linkage disequilibrium in these two population groups (D':1.0, LOD: 0.52, r2: 0.225). The GSTP1 313A/G polymorphism on the other hand, did not display any association with OSSC. The homozygous GSTT1*0 genotype was associated with increased risk of OSCC (OR = 1.71, 95%CI 1.18-2.46) while the homozygous GSTM1*0 genotype was associated with significantly decreased risk of OSCC in the Mixed Ancestry subjects (OR= 0.39, 95%CI 0.25-0.62). CONCLUSIONS: This study shows that the risk of developing OSCC in the South African population can be partly explained by genetic polymorphisms in GST coding genes and their interaction with environmental factors such as tobacco smoke and alcohol consumption.en_ZA
dc.identifier.apacitationLi, D., Dandara, C., & Parker, M. I. (2010). The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. <i>BMC Genetics</i>, http://hdl.handle.net/11427/14886en_ZA
dc.identifier.chicagocitationLi, Dongping, Collet Dandara, and M Iqbal Parker "The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer." <i>BMC Genetics</i> (2010) http://hdl.handle.net/11427/14886en_ZA
dc.identifier.citationLi, D., Dandara, C., & Parker, M. I. (2010). The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC genetics, 11(1), 47.en_ZA
dc.identifier.ris TY - Journal Article AU - Li, Dongping AU - Dandara, Collet AU - Parker, M Iqbal AB - BACKGROUND: The Glutathione S-transferases (GSTs) comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study the effects of polymorphisms in these genes on the risk of developing oesophageal squamous cell carcinoma (OSCC) were evaluated in a hospital-based case-control study in two South African population groups. Genetic polymorphisms in GSTs were investigated in 245 patients and 288 controls samples by PCR-RFLP analysis. RESULTS: The GSTP1 341T variant was associated with significantly increased risk of developing OSCC as observed from the odds ratios for the GSTP1 341C/T and GSTP1 341T/T genotypes (OR = 4.98; 95%CI 3.05-8.11 and OR = 10.9; 95%CI 2.43-49.1, respectively) when compared to the homozygous GSTP1 341C/C genotype. The risk for OSCC in the combined GSTP1 341C/T and T/T genotypes was higher in tobacco smokers (OR = 7.51, 95% CI 3.82-14.7), alcohol consumers (OR = 15.3, 95% CI 1.81-12.9) and those using wood or charcoal for cooking and heating (OR = 12.1, 95% CI 3.26-49) when compared to those who did not smoke tobacco, or did not consume alcohol or user other forms of fuel for cooking and heating. Despite the close proximity of the two GSTP1 SNPs (313A>G and 341C>T), they were not in linkage disequilibrium in these two population groups (D':1.0, LOD: 0.52, r2: 0.225). The GSTP1 313A/G polymorphism on the other hand, did not display any association with OSSC. The homozygous GSTT1*0 genotype was associated with increased risk of OSCC (OR = 1.71, 95%CI 1.18-2.46) while the homozygous GSTM1*0 genotype was associated with significantly decreased risk of OSCC in the Mixed Ancestry subjects (OR= 0.39, 95%CI 0.25-0.62). CONCLUSIONS: This study shows that the risk of developing OSCC in the South African population can be partly explained by genetic polymorphisms in GST coding genes and their interaction with environmental factors such as tobacco smoke and alcohol consumption. DA - 2010 DB - OpenUCT DO - 10.1186/1471-2156-11-47 DP - University of Cape Town J1 - BMC Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer TI - The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer UR - http://hdl.handle.net/11427/14886 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14886
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2156-11-47
dc.identifier.vancouvercitationLi D, Dandara C, Parker MI. The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genetics. 2010; http://hdl.handle.net/11427/14886.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2010 Li et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Geneticsen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcgenet/en_ZA
dc.subject.otherEsophageal Neoplasmsen_ZA
dc.subject.otherRisk Factorsen_ZA
dc.titleThe 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal canceren_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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