Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.advisorHorsnell, Williamen_ZA
dc.contributor.authorDarby, Matthew Gen_ZA
dc.date.accessioned2015-11-13T13:03:06Z
dc.date.available2015-11-13T13:03:06Z
dc.date.issued2012en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractNippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection.en_ZA
dc.identifier.apacitationDarby, M. G. (2012). <i>Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/14954en_ZA
dc.identifier.chicagocitationDarby, Matthew G. <i>"Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2012. http://hdl.handle.net/11427/14954en_ZA
dc.identifier.citationDarby, M. 2012. Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Darby, Matthew G AB - Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells TI - Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells UR - http://hdl.handle.net/11427/14954 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14954
dc.identifier.vancouvercitationDarby MG. Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/14954en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunoIogyen_ZA
dc.titleProtective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cellsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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