Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users
dc.contributor.author | Jones, Erika S Wilshire | |
dc.contributor.author | Rayner, Brian Lindsay | |
dc.date.accessioned | 2021-10-08T07:20:31Z | |
dc.date.available | 2021-10-08T07:20:31Z | |
dc.date.issued | 2015 | |
dc.description.abstract | BACKGROUND: Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of abuse on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation of kidney disease and/or hypertension, who had been abusing methamphetamines. METHODS: The records of patients referred to the renal unit between 2005 and 2013 who had been using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, blood pressure, renal function, renal ultrasound and biopsy findings, complications of chronic kidney disease and comorbidities were recorded. RESULTS: Forty-seven patients were included in the study. Their mean age was 29 years. Hypertension was present in 42 (89.4%) of patients, with malignant hypertension in 21 (44.7%). Forty-five (95.7%) had chronic kidney disease (CKD), and 26 (55.3%) had end-stage renal disease. Renal biopsies were performed in 24 patients. Twelve (50.0%) of the biopsies showed hypertensive changes and 14 (58.3%) mesangiocapillary glomerulonephritis type 1, with deposition of IgM and C3 complement. CONCLUSION: Methamphetamine use is associated with severe hypertension, mesangiocapillary glomerulonephritis and CKD. | |
dc.identifier.apacitation | Jones, E. S. W., & Rayner, B. L. (2015). Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. <i>South African Medical Journal</i>, 105(3), 199 - 177. http://hdl.handle.net/11427/34944 | en_ZA |
dc.identifier.chicagocitation | Jones, Erika S Wilshire, and Brian Lindsay Rayner "Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users." <i>South African Medical Journal</i> 105, 3. (2015): 199 - 177. http://hdl.handle.net/11427/34944 | en_ZA |
dc.identifier.citation | Jones, E.S.W. & Rayner, B.L. 2015. Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. <i>South African Medical Journal.</i> 105(3):199 - 177. http://hdl.handle.net/11427/34944 | en_ZA |
dc.identifier.issn | 0038-2469 | |
dc.identifier.ris | TY - Journal Article AU - Jones, Erika S Wilshire AU - Rayner, Brian Lindsay AB - BACKGROUND: Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of abuse on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation of kidney disease and/or hypertension, who had been abusing methamphetamines. METHODS: The records of patients referred to the renal unit between 2005 and 2013 who had been using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, blood pressure, renal function, renal ultrasound and biopsy findings, complications of chronic kidney disease and comorbidities were recorded. RESULTS: Forty-seven patients were included in the study. Their mean age was 29 years. Hypertension was present in 42 (89.4%) of patients, with malignant hypertension in 21 (44.7%). Forty-five (95.7%) had chronic kidney disease (CKD), and 26 (55.3%) had end-stage renal disease. Renal biopsies were performed in 24 patients. Twelve (50.0%) of the biopsies showed hypertensive changes and 14 (58.3%) mesangiocapillary glomerulonephritis type 1, with deposition of IgM and C3 complement. CONCLUSION: Methamphetamine use is associated with severe hypertension, mesangiocapillary glomerulonephritis and CKD. DA - 2015 DB - OpenUCT DP - University of Cape Town IS - 3 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2015 SM - 0038-2469 T1 - Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users TI - Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users UR - http://hdl.handle.net/11427/34944 ER - | en_ZA |
dc.identifier.uri | http://hdl.handle.net/11427/34944 | |
dc.identifier.vancouvercitation | Jones ESW, Rayner BL. Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. South African Medical Journal. 2015;105(3):199 - 177. http://hdl.handle.net/11427/34944. | en_ZA |
dc.language.iso | eng | |
dc.publisher.department | Department of Medicine | |
dc.publisher.faculty | Faculty of Health Sciences | |
dc.source | South African Medical Journal | |
dc.source.journalissue | 3 | |
dc.source.journalvolume | 105 | |
dc.source.pagination | 199 - 177 | |
dc.source.uri | https://dx.doi.org/10.7196/SAMJ.8731 | |
dc.subject.other | Adult | |
dc.subject.other | Amphetamine-Related Disorders | |
dc.subject.other | Female | |
dc.subject.other | Glomerulonephritis, Membranoproliferative | |
dc.subject.other | Humans | |
dc.subject.other | Hypertension | |
dc.subject.other | Kidney Failure, Chronic | |
dc.subject.other | Male | |
dc.subject.other | Methamphetamine | |
dc.subject.other | Renal Insufficiency, Chronic | |
dc.subject.other | Retrospective Studies | |
dc.subject.other | South Africa | |
dc.subject.other | Young Adult | |
dc.subject.other | Methamphetamine | |
dc.title | Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users | |
dc.type | Journal Article | |
uct.type.publication | Research | |
uct.type.resource | Journal Article |
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