Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users

dc.contributor.authorJones, Erika S Wilshire
dc.contributor.authorRayner, Brian Lindsay
dc.date.accessioned2021-10-08T07:20:31Z
dc.date.available2021-10-08T07:20:31Z
dc.date.issued2015
dc.description.abstractBACKGROUND: Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of abuse on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation of kidney disease and/or hypertension, who had been abusing methamphetamines. METHODS: The records of patients referred to the renal unit between 2005 and 2013 who had been using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, blood pressure, renal function, renal ultrasound and biopsy findings, complications of chronic kidney disease and comorbidities were recorded. RESULTS: Forty-seven patients were included in the study. Their mean age was 29 years. Hypertension was present in 42 (89.4%) of patients, with malignant hypertension in 21 (44.7%). Forty-five (95.7%) had chronic kidney disease (CKD), and 26 (55.3%) had end-stage renal disease. Renal biopsies were performed in 24 patients. Twelve (50.0%) of the biopsies showed hypertensive changes and 14 (58.3%) mesangiocapillary glomerulonephritis type 1, with deposition of IgM and C3 complement. CONCLUSION: Methamphetamine use is associated with severe hypertension, mesangiocapillary glomerulonephritis and CKD.
dc.identifier.apacitationJones, E. S. W., & Rayner, B. L. (2015). Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. <i>South African Medical Journal</i>, 105(3), 199 - 177. http://hdl.handle.net/11427/34944en_ZA
dc.identifier.chicagocitationJones, Erika S Wilshire, and Brian Lindsay Rayner "Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users." <i>South African Medical Journal</i> 105, 3. (2015): 199 - 177. http://hdl.handle.net/11427/34944en_ZA
dc.identifier.citationJones, E.S.W. & Rayner, B.L. 2015. Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. <i>South African Medical Journal.</i> 105(3):199 - 177. http://hdl.handle.net/11427/34944en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Jones, Erika S Wilshire AU - Rayner, Brian Lindsay AB - BACKGROUND: Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of abuse on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation of kidney disease and/or hypertension, who had been abusing methamphetamines. METHODS: The records of patients referred to the renal unit between 2005 and 2013 who had been using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, blood pressure, renal function, renal ultrasound and biopsy findings, complications of chronic kidney disease and comorbidities were recorded. RESULTS: Forty-seven patients were included in the study. Their mean age was 29 years. Hypertension was present in 42 (89.4%) of patients, with malignant hypertension in 21 (44.7%). Forty-five (95.7%) had chronic kidney disease (CKD), and 26 (55.3%) had end-stage renal disease. Renal biopsies were performed in 24 patients. Twelve (50.0%) of the biopsies showed hypertensive changes and 14 (58.3%) mesangiocapillary glomerulonephritis type 1, with deposition of IgM and C3 complement. CONCLUSION: Methamphetamine use is associated with severe hypertension, mesangiocapillary glomerulonephritis and CKD. DA - 2015 DB - OpenUCT DP - University of Cape Town IS - 3 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2015 SM - 0038-2469 T1 - Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users TI - Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users UR - http://hdl.handle.net/11427/34944 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34944
dc.identifier.vancouvercitationJones ESW, Rayner BL. Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. South African Medical Journal. 2015;105(3):199 - 177. http://hdl.handle.net/11427/34944.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue3
dc.source.journalvolume105
dc.source.pagination199 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.8731
dc.subject.otherAdult
dc.subject.otherAmphetamine-Related Disorders
dc.subject.otherFemale
dc.subject.otherGlomerulonephritis, Membranoproliferative
dc.subject.otherHumans
dc.subject.otherHypertension
dc.subject.otherKidney Failure, Chronic
dc.subject.otherMale
dc.subject.otherMethamphetamine
dc.subject.otherRenal Insufficiency, Chronic
dc.subject.otherRetrospective Studies
dc.subject.otherSouth Africa
dc.subject.otherYoung Adult
dc.subject.otherMethamphetamine
dc.titleHypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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