Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers

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dc.contributor.authorEden, Kate E
dc.contributor.authorde Vries, Petrus J
dc.contributor.authorMoss, Jo
dc.contributor.authorRichards, Caroline
dc.contributor.authorOliver, Chris
dc.date.accessioned2015-07-30T03:56:14Z
dc.date.available2015-07-30T03:56:14Z
dc.date.issued2014-05-10
dc.date.updated2015-01-15T17:57:46Z
dc.description.abstractAbstract Background Research reporting prevalence rates of self-injurious and aggressive behaviour in people with tuberous sclerosis complex (TSC) is limited. No studies have compared rates of these behaviours in TSC with those in other syndrome groups matched for degree of disability or investigated risk markers for these behaviours in TSC. Methods Data from the Challenging Behaviour Questionnaire were collected for 37 children, aged 4 to 15 years, with TSC. Odds ratios were used to compare rates of self-injury and aggression in children with TSC with children with idiopathic autism spectrum disorder (ASD), fragile X, Cornelia de Lange and Down syndromes. Characteristics were measured using the Mood Interest and Pleasure Questionnaire, the Activity Questionnaire, the Social Communication Questionnaire, the Repetitive Behaviour Questionnaire, the Wessex Behaviour Schedule and the revised Non-communicating Children Pain Checklist. Mann-Whitney U analyses were used to compare characteristics between individuals with self-injury and aggression and those not showing these behaviours. Results Rates of self-injury and aggression in TSC were 27% and 50%, respectively. These are high but not significantly different from rates in children with Down syndrome or other syndrome groups. Both self-injury and aggression were associated with stereotyped and pain-related behaviours, low mood, hyperactivity, impulsivity and repetitive use of language. Children who engaged in self-injury also had lower levels of interest and pleasure and showed a greater degree of ‘insistence on sameness’ than children who did not self-injure. Aggression was associated with repetitive behaviour. The majority of these associations remained significant when the association with level of adaptive functioning was controlled for. Conclusions Behavioural profiles can be used to identify those most at risk of developing self-injury and aggression. Further research is warranted to understand the influence of such internal factors as mood, ASD symptomatology and pain on challenging behaviour in people with intellectual disability.
dc.identifier.apacitationEden, K. E., de Vries, P. J., Moss, J., Richards, C., & Oliver, C. (2014). Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers. <i>Journal of Neurodevelopmental Disorders</i>, http://hdl.handle.net/11427/13593en_ZA
dc.identifier.chicagocitationEden, Kate E, Petrus J de Vries, Jo Moss, Caroline Richards, and Chris Oliver "Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers." <i>Journal of Neurodevelopmental Disorders</i> (2014) http://hdl.handle.net/11427/13593en_ZA
dc.identifier.citationEden, K. E., de Vries, P. J., Moss, J., Richards, C., & Oliver, C. (2014). Self-injury and aggression in tuberous sclerosis complex: cross-syndrome comparison and associated risk markers. Journal of Neurodevelopmental Disorders, 6(1), 10.
dc.identifier.ris TY - Journal Article AU - Eden, Kate E AU - de Vries, Petrus J AU - Moss, Jo AU - Richards, Caroline AU - Oliver, Chris AB - Abstract Background Research reporting prevalence rates of self-injurious and aggressive behaviour in people with tuberous sclerosis complex (TSC) is limited. No studies have compared rates of these behaviours in TSC with those in other syndrome groups matched for degree of disability or investigated risk markers for these behaviours in TSC. Methods Data from the Challenging Behaviour Questionnaire were collected for 37 children, aged 4 to 15 years, with TSC. Odds ratios were used to compare rates of self-injury and aggression in children with TSC with children with idiopathic autism spectrum disorder (ASD), fragile X, Cornelia de Lange and Down syndromes. Characteristics were measured using the Mood Interest and Pleasure Questionnaire, the Activity Questionnaire, the Social Communication Questionnaire, the Repetitive Behaviour Questionnaire, the Wessex Behaviour Schedule and the revised Non-communicating Children Pain Checklist. Mann-Whitney U analyses were used to compare characteristics between individuals with self-injury and aggression and those not showing these behaviours. Results Rates of self-injury and aggression in TSC were 27% and 50%, respectively. These are high but not significantly different from rates in children with Down syndrome or other syndrome groups. Both self-injury and aggression were associated with stereotyped and pain-related behaviours, low mood, hyperactivity, impulsivity and repetitive use of language. Children who engaged in self-injury also had lower levels of interest and pleasure and showed a greater degree of ‘insistence on sameness’ than children who did not self-injure. Aggression was associated with repetitive behaviour. The majority of these associations remained significant when the association with level of adaptive functioning was controlled for. Conclusions Behavioural profiles can be used to identify those most at risk of developing self-injury and aggression. Further research is warranted to understand the influence of such internal factors as mood, ASD symptomatology and pain on challenging behaviour in people with intellectual disability. DA - 2014-05-10 DB - OpenUCT DO - 10.1186/1866-1955-6-10 DP - University of Cape Town J1 - Journal of Neurodevelopmental Disorders LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers TI - Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers UR - http://hdl.handle.net/11427/13593 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13593
dc.identifier.urihttp://dx.doi.org/10.1186/1866-1955-6-10
dc.identifier.vancouvercitationEden KE, de Vries PJ, Moss J, Richards C, Oliver C. Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers. Journal of Neurodevelopmental Disorders. 2014; http://hdl.handle.net/11427/13593.en_ZA
dc.language.rfc3066en
dc.publisher.departmentDivision of Child and Adolescent Psychiatryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderEden et al.; licensee BioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/2.0*
dc.sourceJournal of Neurodevelopmental Disordersen_ZA
dc.source.urihttp://www.jneurodevdisorders.com/
dc.subject.otherAggressionen_ZA
dc.subject.otherASDen_ZA
dc.subject.otherImpulsivityen_ZA
dc.subject.otherPainen_ZA
dc.subject.otherRepetitive/stereotyped behaviouren_ZA
dc.subject.otherSelf-injuryen_ZA
dc.subject.otherTuberous sclerosis complexen_ZA
dc.titleSelf-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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