Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis

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dc.contributor.authorJingi, Ahmadou M
dc.contributor.authorTankeu, Aurel T
dc.contributor.authorAteba, Narcisse Assene
dc.contributor.authorNoubiap, Jean Jacques
dc.date.accessioned2021-10-08T06:20:20Z
dc.date.available2021-10-08T06:20:20Z
dc.date.issued2017
dc.description.abstractInsulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. An osmotic theory has been evocated but failed to explain the clinical features of the disease. Considering recent findings from basic and clinical research, we discuss the possibility of a synergistic hypothesis based on the simultaneous action of insulin and vascular endothelial growth factor on eye blood vessels. We postulate that exogenous insulin could act synergistically with the vascular endothelial growth factor expressed by ischemic retina so as to trigger vascular proliferation and the worsening of diabetes retinopathy.
dc.identifier.apacitationJingi, A. M., Tankeu, A. T., Ateba, N. A., & Noubiap, J. J. (2017). Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis. <i>BMC Endocrine Disorders</i>, 17(1), 174 - 177. http://hdl.handle.net/11427/34253en_ZA
dc.identifier.chicagocitationJingi, Ahmadou M, Aurel T Tankeu, Narcisse Assene Ateba, and Jean Jacques Noubiap "Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis." <i>BMC Endocrine Disorders</i> 17, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34253en_ZA
dc.identifier.citationJingi, A.M., Tankeu, A.T., Ateba, N.A. & Noubiap, J.J. 2017. Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis. <i>BMC Endocrine Disorders.</i> 17(1):174 - 177. http://hdl.handle.net/11427/34253en_ZA
dc.identifier.issn1472-6823
dc.identifier.ris TY - Journal Article AU - Jingi, Ahmadou M AU - Tankeu, Aurel T AU - Ateba, Narcisse Assene AU - Noubiap, Jean Jacques AB - Insulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. An osmotic theory has been evocated but failed to explain the clinical features of the disease. Considering recent findings from basic and clinical research, we discuss the possibility of a synergistic hypothesis based on the simultaneous action of insulin and vascular endothelial growth factor on eye blood vessels. We postulate that exogenous insulin could act synergistically with the vascular endothelial growth factor expressed by ischemic retina so as to trigger vascular proliferation and the worsening of diabetes retinopathy. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Endocrine Disorders LK - https://open.uct.ac.za PY - 2017 SM - 1472-6823 T1 - Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis TI - Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis UR - http://hdl.handle.net/11427/34253 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34253
dc.identifier.vancouvercitationJingi AM, Tankeu AT, Ateba NA, Noubiap JJ. Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis. BMC Endocrine Disorders. 2017;17(1):174 - 177. http://hdl.handle.net/11427/34253.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceBMC Endocrine Disorders
dc.source.journalissue1
dc.source.journalvolume17
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12902-017-0213-3
dc.subject.otherDiabetic retinopathy
dc.subject.otherInsulin
dc.subject.otherVascular endothelial growth factor
dc.titleMechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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