Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study

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dc.contributor.advisorColvin, Christopher Jen_ZA
dc.contributor.authorBarnett, Whitneyen_ZA
dc.date.accessioned2014-12-26T14:18:45Z
dc.date.available2014-12-26T14:18:45Z
dc.date.issued2012en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe recent scale-up of ART coverage in resource-limited settings has greatly improved access to treatment. However, literature indicates that patients on ART have high rates of non-adherence (32% to 67%), virological failure (5.2%, to 47%) and resistance to ARVs (5.4% to 80%). These patients are failing first- and second-line ART, leaving no treatment options for successful virus suppression. Yet, literature addressing facilitators and barriers faced by patients on secondline ART is scarce. This study examined factors affecting adherence to second-line ART from the perspective of clinic staff as well as second-line failure patients, assessing both individual and structural barriers. Research was conducted at a large primary-care clinic in Khayelitsha, a periurban township in Cape Town, South Africa. A literature review was conducted to present 1) rates of non-adherence, virological failure and resistance and 2) to present known facilitators & barriers faced by patients on ART, with a specific focus on second-line patients. The literature was found via PubMed and Cochrane Central Register of Controlled Trials (CENTRAL), with a preference for studies in low and middle income countries and those including second-line ART populations. The primary research used participants who were drawn from an MSF-run program to support patients failing second-line treatment.en_ZA
dc.identifier.apacitationBarnett, W. (2012). <i>Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/10134en_ZA
dc.identifier.chicagocitationBarnett, Whitney. <i>"Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2012. http://hdl.handle.net/11427/10134en_ZA
dc.identifier.citationBarnett, W. 2012. Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Barnett, Whitney AB - The recent scale-up of ART coverage in resource-limited settings has greatly improved access to treatment. However, literature indicates that patients on ART have high rates of non-adherence (32% to 67%), virological failure (5.2%, to 47%) and resistance to ARVs (5.4% to 80%). These patients are failing first- and second-line ART, leaving no treatment options for successful virus suppression. Yet, literature addressing facilitators and barriers faced by patients on secondline ART is scarce. This study examined factors affecting adherence to second-line ART from the perspective of clinic staff as well as second-line failure patients, assessing both individual and structural barriers. Research was conducted at a large primary-care clinic in Khayelitsha, a periurban township in Cape Town, South Africa. A literature review was conducted to present 1) rates of non-adherence, virological failure and resistance and 2) to present known facilitators & barriers faced by patients on ART, with a specific focus on second-line patients. The literature was found via PubMed and Cochrane Central Register of Controlled Trials (CENTRAL), with a preference for studies in low and middle income countries and those including second-line ART populations. The primary research used participants who were drawn from an MSF-run program to support patients failing second-line treatment. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study TI - Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study UR - http://hdl.handle.net/11427/10134 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10134
dc.identifier.vancouvercitationBarnett W. Barriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10134en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.titleBarriers to adherence in patients failing second-line antiretroviral treatment in a township in South Africa: a qualitative research studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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