The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice

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dc.contributor.advisorCairncross, Lydia
dc.contributor.advisorPanieri, Eugenio
dc.contributor.authorPickard, Henri Du Plessis
dc.date.accessioned2020-01-23T12:44:24Z
dc.date.available2020-01-23T12:44:24Z
dc.date.issued2019
dc.date.updated2020-01-22T11:28:02Z
dc.description.abstractBackground: Desmoid tumours (DTs) are rare soft tissue tumours that do not metastasise but are locally aggressive. Management options are varied and the response to treatment can be unpredictable. Aim: The aim of this study was to describe the clinical presentation, management strategies and outcomes for adult patients who were treated for DT. Setting: The study was conducted at Groote Schuur Hospital in Cape Town, South Africa and all patients from 2003 to 2016 who presented with DT were included. Method: This was a retrospective review of records. Data collected included: demographics, DT-associated conditions, site and size of tumour, histological findings, treatment modalities, follow-up and outcomes. Results: Seventy patients with histologically confirmed DT were identified. The majority were women (86%) and 77% presented with a painless mass. The commonest site was the anterior abdominal wall (47%). Definitive surgery was performed in 46 (66%) patients, whereas 13 (19%) had definitive radiotherapy. Nine patients received adjuvant radiotherapy post-surgery for involved or close margins. Recurrence developed in 20% patients post-surgery. In the primary radiotherapy group, one patient had disease progression. Two patients with mesenteric DT died because of bowel obstruction. Conclusion: This retrospective review of patients affected by DT at a single centre demonstrates the rarity of the condition, the unpredictable natural history and the variety of treatment options available. Many of our findings are similar to other published studies, except the mean size of DT which was bigger. Treatment outcomes following surgery or radiotherapy seem acceptable, although study limitations are noted.
dc.identifier.apacitationPickard, H. D. P. (2019). <i>The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice</i>. (). ,Faculty of Health Sciences ,Division of General Surgery. Retrieved from http://hdl.handle.net/11427/30790en_ZA
dc.identifier.chicagocitationPickard, Henri Du Plessis. <i>"The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice."</i> ., ,Faculty of Health Sciences ,Division of General Surgery, 2019. http://hdl.handle.net/11427/30790en_ZA
dc.identifier.citationPickard, H.D.P. 2019. The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice. . ,Faculty of Health Sciences ,Division of General Surgery. http://hdl.handle.net/11427/30790en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pickard, Henri Du Plessis AB - Background: Desmoid tumours (DTs) are rare soft tissue tumours that do not metastasise but are locally aggressive. Management options are varied and the response to treatment can be unpredictable. Aim: The aim of this study was to describe the clinical presentation, management strategies and outcomes for adult patients who were treated for DT. Setting: The study was conducted at Groote Schuur Hospital in Cape Town, South Africa and all patients from 2003 to 2016 who presented with DT were included. Method: This was a retrospective review of records. Data collected included: demographics, DT-associated conditions, site and size of tumour, histological findings, treatment modalities, follow-up and outcomes. Results: Seventy patients with histologically confirmed DT were identified. The majority were women (86%) and 77% presented with a painless mass. The commonest site was the anterior abdominal wall (47%). Definitive surgery was performed in 46 (66%) patients, whereas 13 (19%) had definitive radiotherapy. Nine patients received adjuvant radiotherapy post-surgery for involved or close margins. Recurrence developed in 20% patients post-surgery. In the primary radiotherapy group, one patient had disease progression. Two patients with mesenteric DT died because of bowel obstruction. Conclusion: This retrospective review of patients affected by DT at a single centre demonstrates the rarity of the condition, the unpredictable natural history and the variety of treatment options available. Many of our findings are similar to other published studies, except the mean size of DT which was bigger. Treatment outcomes following surgery or radiotherapy seem acceptable, although study limitations are noted. DA - 2019 DB - OpenUCT DP - University of Cape Town KW - Surgery LK - https://open.uct.ac.za PY - 2019 T1 - The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice TI - The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice UR - http://hdl.handle.net/11427/30790 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/30790
dc.identifier.vancouvercitationPickard HDP. The management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice. []. ,Faculty of Health Sciences ,Division of General Surgery, 2019 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/30790en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDivision of General Surgery
dc.publisher.facultyFaculty of Health Sciences
dc.subjectSurgery
dc.titleThe management of desmoid tumours at Groote Schuur Hospital: A retrospective review of current practice
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMed
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