Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans

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dc.contributor.authorMacharia, M
dc.contributor.authorKengne, A P
dc.contributor.authorBlackhurst, D M
dc.contributor.authorErasmus, R T
dc.contributor.authorHoffmann, M
dc.contributor.authorMatsha, T E
dc.date.accessioned2021-10-08T07:08:32Z
dc.date.available2021-10-08T07:08:32Z
dc.date.issued2014
dc.description.abstractWe evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who were stratified by diabetes status and body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure of subclinical CVD. Indices of PON1 and oxidative status were determined by measuring levels and activities (paraoxonase and arylesterase) of PON1, antioxidant activity (ferric reducing antioxidant power and trolox equivalent antioxidant capacity), and lipid peroxidation markers (malondialdehyde and oxidized LDL). Diabetic subjects (28.9%) displayed a significant decrease in PON1 status and antioxidant activity as well as increase in oxidized LDL and malondialdehyde. A similar profile was apparent across increasing BMI categories. CIMT was higher in diabetic than nondiabetic subjects but showed no variation across BMI categories. Overall, CIMT correlated negatively with indices of antioxidant activity and positively with measures of lipid oxidation. Sex, age, BMI, and diabetes altogether explained 29.2% of CIMT, with no further improvement from adding PON1 and/or antioxidant status indices. Though indices of PON1 and oxidative status correlate with CIMT, their measurements may not be useful for identifying subjects at high CVD risk in this population.
dc.identifier.apacitationMacharia, M., Kengne, A. P., Blackhurst, D. M., Erasmus, R. T., Hoffmann, M., & Matsha, T. E. (2014). Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans. <i>Oxidative Medicine and Cellular Longevity</i>, 2014(4), 174 - 177. http://hdl.handle.net/11427/34602en_ZA
dc.identifier.chicagocitationMacharia, M, A P Kengne, D M Blackhurst, R T Erasmus, M Hoffmann, and T E Matsha "Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans." <i>Oxidative Medicine and Cellular Longevity</i> 2014, 4. (2014): 174 - 177. http://hdl.handle.net/11427/34602en_ZA
dc.identifier.citationMacharia, M., Kengne, A.P., Blackhurst, D.M., Erasmus, R.T., Hoffmann, M. & Matsha, T.E. 2014. Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans. <i>Oxidative Medicine and Cellular Longevity.</i> 2014(4):174 - 177. http://hdl.handle.net/11427/34602en_ZA
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.ris TY - Journal Article AU - Macharia, M AU - Kengne, A P AU - Blackhurst, D M AU - Erasmus, R T AU - Hoffmann, M AU - Matsha, T E AB - We evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who were stratified by diabetes status and body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure of subclinical CVD. Indices of PON1 and oxidative status were determined by measuring levels and activities (paraoxonase and arylesterase) of PON1, antioxidant activity (ferric reducing antioxidant power and trolox equivalent antioxidant capacity), and lipid peroxidation markers (malondialdehyde and oxidized LDL). Diabetic subjects (28.9%) displayed a significant decrease in PON1 status and antioxidant activity as well as increase in oxidized LDL and malondialdehyde. A similar profile was apparent across increasing BMI categories. CIMT was higher in diabetic than nondiabetic subjects but showed no variation across BMI categories. Overall, CIMT correlated negatively with indices of antioxidant activity and positively with measures of lipid oxidation. Sex, age, BMI, and diabetes altogether explained 29.2% of CIMT, with no further improvement from adding PON1 and/or antioxidant status indices. Though indices of PON1 and oxidative status correlate with CIMT, their measurements may not be useful for identifying subjects at high CVD risk in this population. DA - 2014 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - Oxidative Medicine and Cellular Longevity LK - https://open.uct.ac.za PY - 2014 SM - 1942-0900 SM - 1942-0994 T1 - Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans TI - Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans UR - http://hdl.handle.net/11427/34602 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34602
dc.identifier.vancouvercitationMacharia M, Kengne AP, Blackhurst DM, Erasmus RT, Hoffmann M, Matsha TE. Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans. Oxidative Medicine and Cellular Longevity. 2014;2014(4):174 - 177. http://hdl.handle.net/11427/34602.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Chemical Pathology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceOxidative Medicine and Cellular Longevity
dc.source.journalissue4
dc.source.journalvolume2014
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1155/2014/135650
dc.subject.otherAdult
dc.subject.otherAfrican Continental Ancestry Group
dc.subject.otherAged
dc.subject.otherAntioxidants
dc.subject.otherAryldialkylphosphatase
dc.subject.otherBody Mass Index
dc.subject.otherCarboxylic Ester Hydrolases
dc.subject.otherCardiovascular Diseases
dc.subject.otherCarotid Intima-Media Thickness
dc.subject.otherDiabetes Mellitus, Type 2
dc.subject.otherHumans
dc.subject.otherLipoproteins, LDL
dc.subject.otherMale
dc.subject.otherMalondialdehyde
dc.subject.otherMiddle Aged
dc.titleIndices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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