Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet?
| dc.contributor.author | Senekal, Marjanne | |
| dc.date.accessioned | 2016-06-08T08:36:19Z | |
| dc.date.available | 2016-06-08T08:36:19Z | |
| dc.date.issued | 2012 | |
| dc.date.updated | 2016-06-08T08:33:59Z | |
| dc.description.abstract | Interactions between genotype and dietary intake include genetic moderation of the effect of dietary intake on disease development (nutrigenetics). Research on nutrigenetics has focused mainly on single-nucleotide polymorphisms (SNPs) and supports the notion that interactions between genes, diet, other lifestyle factors, disease, and time (life cycle span), contribute to the risk of most polygenic nutritionrelated diseases. Typically, genotype-based personalised nutrition involves genotyping for a number of susceptibility SNPs associated with the prevention, or management, of a particular disease. Dietary advice is then personalised to the individual's genotype to ensure optimal prevention or treatment outcomes. To ensure evidence-based practice, research design and methodology, applied in the investigation of relevant associations, and confirmation of causality, should be appropriate and rigorous. The process of identifying SNPs associated with disease patterns is ongoing. Of note is that the combined effect on body mass index of the SNPs at the currently confirmed 32 loci is a modest 1.45%, bearing in mind that the estimated heritability of obesity is 40-70%. Conclusions formulated by various researchers on the translation of nutrigenetics research into personalised nutrition, including obesity prevention and management, indicate that scientists hold the opinion that more research is necessary before evidence-based practice in this area can be guaranteed. | en_ZA |
| dc.identifier.apacitation | Senekal, M. (2012). Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet?. <i>South African Journal of Clinical Nutrition</i>, http://hdl.handle.net/11427/19937 | en_ZA |
| dc.identifier.chicagocitation | Senekal, Marjanne "Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet?." <i>South African Journal of Clinical Nutrition</i> (2012) http://hdl.handle.net/11427/19937 | en_ZA |
| dc.identifier.citation | Senekal, M. (2012). Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet?. South African Journal of Clinical Nutrition, 25(1), 9-14. | en_ZA |
| dc.identifier.issn | 1607-0658 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Senekal, Marjanne AB - Interactions between genotype and dietary intake include genetic moderation of the effect of dietary intake on disease development (nutrigenetics). Research on nutrigenetics has focused mainly on single-nucleotide polymorphisms (SNPs) and supports the notion that interactions between genes, diet, other lifestyle factors, disease, and time (life cycle span), contribute to the risk of most polygenic nutritionrelated diseases. Typically, genotype-based personalised nutrition involves genotyping for a number of susceptibility SNPs associated with the prevention, or management, of a particular disease. Dietary advice is then personalised to the individual's genotype to ensure optimal prevention or treatment outcomes. To ensure evidence-based practice, research design and methodology, applied in the investigation of relevant associations, and confirmation of causality, should be appropriate and rigorous. The process of identifying SNPs associated with disease patterns is ongoing. Of note is that the combined effect on body mass index of the SNPs at the currently confirmed 32 loci is a modest 1.45%, bearing in mind that the estimated heritability of obesity is 40-70%. Conclusions formulated by various researchers on the translation of nutrigenetics research into personalised nutrition, including obesity prevention and management, indicate that scientists hold the opinion that more research is necessary before evidence-based practice in this area can be guaranteed. DA - 2012 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Clinical Nutrition LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 SM - 1607-0658 T1 - Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet? TI - Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet? UR - http://hdl.handle.net/11427/19937 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/19937 | |
| dc.identifier.uri | http://www.sajcn.com/index.php/SAJCN/article/viewArticle/611 | |
| dc.identifier.vancouvercitation | Senekal M. Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet?. South African Journal of Clinical Nutrition. 2012; http://hdl.handle.net/11427/19937. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | MedPharm Publications | en_ZA |
| dc.publisher.department | Division of Human Nutrition | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.rights | Creative Commons Attribution-Noncommercial-No Derivative Works 2.5 South Africa License | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/za/ | en_ZA |
| dc.source | South African Journal of Clinical Nutrition | en_ZA |
| dc.source.uri | http://www.sajcn.co.za/index.php/SAJCN | |
| dc.subject.other | nutrigenetics | |
| dc.subject.other | obesity | |
| dc.subject.other | genotype | |
| dc.subject.other | personalised nutrition | |
| dc.subject.other | weight management | |
| dc.title | Genotype-based personalised nutrition for obesity prevention and treatment: are we there yet? | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | ||
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |