Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks

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dc.contributor.authorMartin, Darren Pen_ZA
dc.contributor.authorLefeuvre, Pierreen_ZA
dc.contributor.authorVarsani, Arvinden_ZA
dc.contributor.authorHoareau, Murielleen_ZA
dc.contributor.authorSemegni, Jean-Yvesen_ZA
dc.contributor.authorDijoux, Bettyen_ZA
dc.contributor.authorVincent, Claireen_ZA
dc.contributor.authorReynaud, Bernarden_ZA
dc.contributor.authorLett, Jean-Michelen_ZA
dc.date.accessioned2015-12-28T06:47:46Z
dc.date.available2015-12-28T06:47:46Z
dc.date.issued2011en_ZA
dc.description.abstractAuthor Summary Genetic recombination between viruses is a form of parasexual reproduction during which two parental viruses each contribute genetic information to an offspring, or recombinant, virus. Unlike with sexual reproduction, however, recombination in viruses can even involve the transfer of sequences between the members of distantly related species. When parental genomes are very distantly related, it is anticipated that recombination between them runs the risk of producing defective offspring. The reason for this is that the interactions between different parts of genomes and the proteins they encode (such as between different viral proteins or between viral proteins and the virus genomic DNA or RNA) often depend on particular co-evolved binding sites that recognize one another. When in a recombinant genome the partners in a binding site pair are each inherited from different parents there is a possibility that they will not interact with one another properly. Here we examine recombinant genomes arising during experimental mixed infections of two distantly related viruses to detect evidence that intra-genome interaction networks are broadly preserved in these genomes. We show this preservation is so strict that patterns of recombination in these viruses can even be used to identify the interacting regions within their genomes.en_ZA
dc.identifier.apacitationMartin, D. P., Lefeuvre, P., Varsani, A., Hoareau, M., Semegni, J., Dijoux, B., ... Lett, J. (2011). Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks. <i>PLoS One</i>, http://hdl.handle.net/11427/16049en_ZA
dc.identifier.chicagocitationMartin, Darren P, Pierre Lefeuvre, Arvind Varsani, Murielle Hoareau, Jean-Yves Semegni, Betty Dijoux, Claire Vincent, Bernard Reynaud, and Jean-Michel Lett "Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks." <i>PLoS One</i> (2011) http://hdl.handle.net/11427/16049en_ZA
dc.identifier.citationMartin, D. P., Lefeuvre, P., Varsani, A., Hoareau, M., Semegni, J. Y., Dijoux, B., ... & Lett, J. M. (2011). Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks. PLoS Pathog, 7(9), e1002203. doi:10.1371/journal.ppat.1002203en_ZA
dc.identifier.ris TY - Journal Article AU - Martin, Darren P AU - Lefeuvre, Pierre AU - Varsani, Arvind AU - Hoareau, Murielle AU - Semegni, Jean-Yves AU - Dijoux, Betty AU - Vincent, Claire AU - Reynaud, Bernard AU - Lett, Jean-Michel AB - Author Summary Genetic recombination between viruses is a form of parasexual reproduction during which two parental viruses each contribute genetic information to an offspring, or recombinant, virus. Unlike with sexual reproduction, however, recombination in viruses can even involve the transfer of sequences between the members of distantly related species. When parental genomes are very distantly related, it is anticipated that recombination between them runs the risk of producing defective offspring. The reason for this is that the interactions between different parts of genomes and the proteins they encode (such as between different viral proteins or between viral proteins and the virus genomic DNA or RNA) often depend on particular co-evolved binding sites that recognize one another. When in a recombinant genome the partners in a binding site pair are each inherited from different parents there is a possibility that they will not interact with one another properly. Here we examine recombinant genomes arising during experimental mixed infections of two distantly related viruses to detect evidence that intra-genome interaction networks are broadly preserved in these genomes. We show this preservation is so strict that patterns of recombination in these viruses can even be used to identify the interacting regions within their genomes. DA - 2011 DB - OpenUCT DO - 10.1371/journal.ppat.1002203 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks TI - Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks UR - http://hdl.handle.net/11427/16049 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16049
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1002203
dc.identifier.vancouvercitationMartin DP, Lefeuvre P, Varsani A, Hoareau M, Semegni J, Dijoux B, et al. Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks. PLoS One. 2011; http://hdl.handle.net/11427/16049.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2011 Martin et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherRecombinant proteinsen_ZA
dc.subject.otherDNA recombinationen_ZA
dc.subject.otherPlant genomicsen_ZA
dc.subject.otherProtein interactionsen_ZA
dc.subject.otherViral genomicsen_ZA
dc.subject.otherGenomic imprintingen_ZA
dc.subject.otherStructural genomicsen_ZA
dc.subject.otherProtein-protein interactionsen_ZA
dc.titleComplex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networksen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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