A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa

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dc.contributor.authorCharlton, Karen E
dc.contributor.authorSteyn, Krisela
dc.contributor.authorLevitt, Naomi S
dc.contributor.authorPeer, Nasheeta
dc.contributor.authorJonathan, Deborah
dc.contributor.authorGogela, Theresa
dc.contributor.authorRossouw, Katja
dc.contributor.authorGwebushe, Nomonde
dc.contributor.authorLombard, Carl J
dc.date.accessioned2021-10-08T07:15:58Z
dc.date.available2021-10-08T07:15:58Z
dc.date.issued2008
dc.description.abstractOBJECTIVE: To assess the impact of a food-based intervention on blood pressure (BP) in free-living South African men and women aged 50-75 years, with drug-treated mild-to-moderate hypertension. METHODS: A double-blind controlled trial was undertaken in eighty drug-treated mild-to-moderate hypertensive subjects randomised to an intervention (n 40) or control (n 40) arm. The intervention was 8-week provision of six food items with a modified cation content (salt replacement (SOLO ), bread, margarine, stock cubes, soup mix and a flavour enhancer) and 500 ml of maas (fermented milk)/d. The control diet provided the same quantities of the targeted foods but of standard commercial composition and 500 ml/d of artificially sweetened cooldrink. FINDINGS: The intervention effect estimated as the contrast of the within-diet group changes in BP from baseline to post-intervention was a significant reduction of 6.2 mmHg (95 % CI 0.9, 11.4) for systolic BP. The largest intervention effect in 24 h BP was for wake systolic BP with a reduction of 5.1 mmHg (95 % CI 0.4, 9.9). For wake diastolic BP the reduction was 2.7 mmHg (95 % CI -0.2, 5.6). CONCLUSIONS: Modification of the cation content of a limited number of commonly consumed foods lowers BP by a clinically significant magnitude in treated South African hypertensive patients of low socio-economic status. The magnitude of BP reduction provides motivation for a public health strategy that could be adopted through lobbying of the food industry by consumer and health agencies.
dc.identifier.apacitationCharlton, K. E., Steyn, K., Levitt, N. S., Peer, N., Jonathan, D., Gogela, T., ... Lombard, C. J. (2008). A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa. <i>Public Health Nutrition</i>, 11(12), 1397 - 177. http://hdl.handle.net/11427/34734en_ZA
dc.identifier.chicagocitationCharlton, Karen E, Krisela Steyn, Naomi S Levitt, Nasheeta Peer, Deborah Jonathan, Theresa Gogela, Katja Rossouw, Nomonde Gwebushe, and Carl J Lombard "A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa." <i>Public Health Nutrition</i> 11, 12. (2008): 1397 - 177. http://hdl.handle.net/11427/34734en_ZA
dc.identifier.citationCharlton, K.E., Steyn, K., Levitt, N.S., Peer, N., Jonathan, D., Gogela, T., Rossouw, K. & Gwebushe, N. et al. 2008. A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa. <i>Public Health Nutrition.</i> 11(12):1397 - 177. http://hdl.handle.net/11427/34734en_ZA
dc.identifier.issn1368-9800
dc.identifier.issn1475-2727
dc.identifier.ris TY - Journal Article AU - Charlton, Karen E AU - Steyn, Krisela AU - Levitt, Naomi S AU - Peer, Nasheeta AU - Jonathan, Deborah AU - Gogela, Theresa AU - Rossouw, Katja AU - Gwebushe, Nomonde AU - Lombard, Carl J AB - OBJECTIVE: To assess the impact of a food-based intervention on blood pressure (BP) in free-living South African men and women aged 50-75 years, with drug-treated mild-to-moderate hypertension. METHODS: A double-blind controlled trial was undertaken in eighty drug-treated mild-to-moderate hypertensive subjects randomised to an intervention (n 40) or control (n 40) arm. The intervention was 8-week provision of six food items with a modified cation content (salt replacement (SOLO ), bread, margarine, stock cubes, soup mix and a flavour enhancer) and 500 ml of maas (fermented milk)/d. The control diet provided the same quantities of the targeted foods but of standard commercial composition and 500 ml/d of artificially sweetened cooldrink. FINDINGS: The intervention effect estimated as the contrast of the within-diet group changes in BP from baseline to post-intervention was a significant reduction of 6.2 mmHg (95 % CI 0.9, 11.4) for systolic BP. The largest intervention effect in 24 h BP was for wake systolic BP with a reduction of 5.1 mmHg (95 % CI 0.4, 9.9). For wake diastolic BP the reduction was 2.7 mmHg (95 % CI -0.2, 5.6). CONCLUSIONS: Modification of the cation content of a limited number of commonly consumed foods lowers BP by a clinically significant magnitude in treated South African hypertensive patients of low socio-economic status. The magnitude of BP reduction provides motivation for a public health strategy that could be adopted through lobbying of the food industry by consumer and health agencies. DA - 2008 DB - OpenUCT DP - University of Cape Town IS - 12 J1 - Public Health Nutrition LK - https://open.uct.ac.za PY - 2008 SM - 1368-9800 SM - 1475-2727 T1 - A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa TI - A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa UR - http://hdl.handle.net/11427/34734 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34734
dc.identifier.vancouvercitationCharlton KE, Steyn K, Levitt NS, Peer N, Jonathan D, Gogela T, et al. A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa. Public Health Nutrition. 2008;11(12):1397 - 177. http://hdl.handle.net/11427/34734.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Endocrinology and Diabetology
dc.publisher.facultyFaculty of Health Sciences
dc.sourcePublic Health Nutrition
dc.source.journalissue12
dc.source.journalvolume11
dc.source.pagination1397 - 177
dc.source.urihttps://dx.doi.org/10.1017/S136898000800342X
dc.subject.otherRandomised controlled trial
dc.subject.otherSodium reduction
dc.subject.otherPotassium increase
dc.subject.otherDietary intervention
dc.subject.otherBlood pressure
dc.subject.otherHypertension
dc.subject.otherSouth Africans
dc.titleA food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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