The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
| dc.contributor.advisor | Verburgh, Estelle | |
| dc.contributor.author | Simba, Kudakwashe | |
| dc.date.accessioned | 2026-01-30T09:09:02Z | |
| dc.date.available | 2026-01-30T09:09:02Z | |
| dc.date.issued | 2025 | |
| dc.date.updated | 2026-01-28T07:28:08Z | |
| dc.description.abstract | Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion. | |
| dc.identifier.apacitation | Simba, K. (2025). <i>The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/42775 | en_ZA |
| dc.identifier.chicagocitation | Simba, Kudakwashe. <i>"The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2025. http://hdl.handle.net/11427/42775 | en_ZA |
| dc.identifier.citation | Simba, K. 2025. The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma. . University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/42775 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Simba, Kudakwashe AB - Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - HIV KW - Hodgkin lymphoma LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma TI - The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma UR - http://hdl.handle.net/11427/42775 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/42775 | |
| dc.identifier.vancouvercitation | Simba K. The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma. []. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/42775 | en_ZA |
| dc.language.iso | en | |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Medicine | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject | HIV | |
| dc.subject | Hodgkin lymphoma | |
| dc.title | The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | Masters |