Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration

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dc.contributor.advisorFranz, Thomasen_ZA
dc.contributor.advisorKrynauw, Hugoen_ZA
dc.contributor.advisorBezuidenhout, Deonen_ZA
dc.contributor.authorKhatib, Rodaina Omaren_ZA
dc.date.accessioned2014-07-29T09:04:08Z
dc.date.available2014-07-29T09:04:08Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractCurrent replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation.en_ZA
dc.identifier.apacitationKhatib, R. O. (2013). <i>Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3408en_ZA
dc.identifier.chicagocitationKhatib, Rodaina Omar. <i>"Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/3408en_ZA
dc.identifier.citationKhatib, R. 2013. Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Khatib, Rodaina Omar AB - Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration TI - Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration UR - http://hdl.handle.net/11427/3408 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3408
dc.identifier.vancouvercitationKhatib RO. Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3408en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleOptimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regenerationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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