Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study

dc.contributor.authorNtusi, Ntobekoen_ZA
dc.contributor.authorHolloway, Cameronen_ZA
dc.contributor.authorFrancis, Janeen_ZA
dc.contributor.authorDavis, Anneen_ZA
dc.contributor.authorLevelt, Eylemen_ZA
dc.contributor.authorPiechnik, Stefanen_ZA
dc.contributor.authorFerreira, Vanessaen_ZA
dc.contributor.authorMatthews, Paulen_ZA
dc.contributor.authorWordsworth, Paulen_ZA
dc.contributor.authorKaramitsos, Theodorosen_ZA
dc.contributor.authorNeubauer, Stefanen_ZA
dc.date.accessioned2015-12-07T08:47:08Z
dc.date.available2015-12-07T08:47:08Z
dc.date.issued2015en_ZA
dc.description.abstractRheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) commonly involve the cardiovascular system and are associated with significant morbidity and mortality, driven by cardiovascular inflammation, microvascular and diastolic dysfunction and fibrosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, strain, ischaemia, altered vascular function, perfusion, inflammation and fibrosis; magnetic resonance spectroscopy (MRS) provides further insights into the status of myocardial energetics and lipidosis. To date, there have been no cardiovascular MRS studies in RA and SLE patients. We hypothesised that RA and SLE would be associated with impaired myocardial energetics and lipidosis.en_ZA
dc.identifier.apacitationNtusi, N., Holloway, C., Francis, J., Davis, A., Levelt, E., Piechnik, S., ... Neubauer, S. (2015). Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study. <i>Journal of Cardiovascular Magnetic Resonance</i>, http://hdl.handle.net/11427/15628en_ZA
dc.identifier.chicagocitationNtusi, Ntobeko, Cameron Holloway, Jane Francis, Anne Davis, Eylem Levelt, Stefan Piechnik, Vanessa Ferreira, et al "Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study." <i>Journal of Cardiovascular Magnetic Resonance</i> (2015) http://hdl.handle.net/11427/15628en_ZA
dc.identifier.citationNtusi, N. A., Holloway, C., Francis, J. M., Davis, A., Levelt, E., Piechnik, S. K., ... & Neubauer, S. (2015). Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance, 17(Suppl 1), O99.en_ZA
dc.identifier.ris TY - Journal Article AU - Ntusi, Ntobeko AU - Holloway, Cameron AU - Francis, Jane AU - Davis, Anne AU - Levelt, Eylem AU - Piechnik, Stefan AU - Ferreira, Vanessa AU - Matthews, Paul AU - Wordsworth, Paul AU - Karamitsos, Theodoros AU - Neubauer, Stefan AB - Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) commonly involve the cardiovascular system and are associated with significant morbidity and mortality, driven by cardiovascular inflammation, microvascular and diastolic dysfunction and fibrosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, strain, ischaemia, altered vascular function, perfusion, inflammation and fibrosis; magnetic resonance spectroscopy (MRS) provides further insights into the status of myocardial energetics and lipidosis. To date, there have been no cardiovascular MRS studies in RA and SLE patients. We hypothesised that RA and SLE would be associated with impaired myocardial energetics and lipidosis. DA - 2015 DB - OpenUCT DO - 10.1186/1532-429X-17-S1-O99 DP - University of Cape Town J1 - Journal of Cardiovascular Magnetic Resonance LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study TI - Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study UR - http://hdl.handle.net/11427/15628 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15628
dc.identifier.urihttp://dx.doi.org/10.1186/1532-429X-17-S1-O99
dc.identifier.vancouvercitationNtusi N, Holloway C, Francis J, Davis A, Levelt E, Piechnik S, et al. Impaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2015; http://hdl.handle.net/11427/15628.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Ntusi et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceJournal of Cardiovascular Magnetic Resonanceen_ZA
dc.source.urihttp://www.jcmr-online.com/en_ZA
dc.subject.otherRheumatoid arthritis (RA)en_ZA
dc.subject.othersystemic lupus erythematosus (SLE)en_ZA
dc.subject.othercardiovascular inflammationen_ZA
dc.titleImpaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Ntusi_Impaired_energetics_2015.pdf
Size:
195.62 KB
Format:
Adobe Portable Document Format
Description:
Collections