Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision

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dc.contributor.advisorGray, Clive Men_ZA
dc.contributor.advisorOlivier, Abraham Jacobusen_ZA
dc.contributor.authorHarryparsad, Rushilen_ZA
dc.date.accessioned2016-07-21T11:04:46Z
dc.date.available2016-07-21T11:04:46Z
dc.date.issued2016en_ZA
dc.description.abstractBackground: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target cells present in the foreskin. The more inflamed inner foreskin may be increasing the risk of a productive HIV-1 infection. The aims of this dissertation was to a) examine the levels of keratinisation in the inner and outer foreskins after MMC; b) investigate the number of Langerhans, Ki67+ and CD4+ T cells in the inner and outer foreskin and c) identify the impact of asymptomatic STIs on the numbers and proliferative capacity of foreskin-resident Langerhans and CD4+ T cells.en_ZA
dc.identifier.apacitationHarryparsad, R. (2016). <i>Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/20563en_ZA
dc.identifier.chicagocitationHarryparsad, Rushil. <i>"Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2016. http://hdl.handle.net/11427/20563en_ZA
dc.identifier.citationHarryparsad, R. 2016. Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Harryparsad, Rushil AB - Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target cells present in the foreskin. The more inflamed inner foreskin may be increasing the risk of a productive HIV-1 infection. The aims of this dissertation was to a) examine the levels of keratinisation in the inner and outer foreskins after MMC; b) investigate the number of Langerhans, Ki67+ and CD4+ T cells in the inner and outer foreskin and c) identify the impact of asymptomatic STIs on the numbers and proliferative capacity of foreskin-resident Langerhans and CD4+ T cells. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision TI - Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision UR - http://hdl.handle.net/11427/20563 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20563
dc.identifier.vancouvercitationHarryparsad R. Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20563en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Sciences and Immunologyen_ZA
dc.titleCharacterisation of mucosal tissue in the foreskin after voluntary medical male circumcisionen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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