MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis

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dc.contributor.authorScott, Christiaanen_ZA
dc.contributor.authorKalla, Asgaren_ZA
dc.date.accessioned2015-11-18T03:56:09Z
dc.date.available2015-11-18T03:56:09Z
dc.date.issued2011en_ZA
dc.description.abstractIntroduction; Myasthenia Gravis associated with Juvenile Idiopathic Arthritis has been reported in 5children with various subtypes of JIA [1,2]. Methods: We present a 17year old girl known with Rheumatoid Factor Positive Polyarticular Juvenile Idiopathic Arthritis for 4 years who developed Myasthenia Gravis while on therapy with Methotrexate, Prednisone and Ibuprofen. Results: This patient presented to the emergency room with a respiratory infection. She had been feeling weak and had noticed tongue weakness and difficulty swallowing, which had worsened significantly since the respiratory infection. On examination she was found to have clinical signs of Right Middle Lobe pneumonia and was found to be weak, especially in her proximal muscle groups. She had bilateral ptosis as well as facial weakness. She had active arthritis in multiple joints. Despite intravenous antibiotics and full supportive management she deteriorated rapidly, and within 12 hours required intubation and ventilation. The patient was found to have high ACH receptor antibodies and responded dramatically to pyridostygmine therapy, confirming the diagnosis of MG. High prednisone and azathioprine have been added to her regime. Discussion: Myasthenia Gravis is a rare association with JIA. The majority of cases appear to be associated with oligo-articular JIA. This patient presented after an acute infection and a recent worsening in her JIA symptoms.en_ZA
dc.identifier.apacitationScott, C., & Kalla, A. (2011). MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis. <i>Pediatric Rheumatology</i>, http://hdl.handle.net/11427/15067en_ZA
dc.identifier.chicagocitationScott, Christiaan, and Asgar Kalla "MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis." <i>Pediatric Rheumatology</i> (2011) http://hdl.handle.net/11427/15067en_ZA
dc.identifier.citationScott, C., & Kalla, A. (2011). MyastheniaGravis (MG) in a patient with Juvenile Idiopathic Arthritis. Pediatric Rheumatology, 9(Suppl 1), P185.en_ZA
dc.identifier.ris TY - Journal Article AU - Scott, Christiaan AU - Kalla, Asgar AB - Introduction; Myasthenia Gravis associated with Juvenile Idiopathic Arthritis has been reported in 5children with various subtypes of JIA [1,2]. Methods: We present a 17year old girl known with Rheumatoid Factor Positive Polyarticular Juvenile Idiopathic Arthritis for 4 years who developed Myasthenia Gravis while on therapy with Methotrexate, Prednisone and Ibuprofen. Results: This patient presented to the emergency room with a respiratory infection. She had been feeling weak and had noticed tongue weakness and difficulty swallowing, which had worsened significantly since the respiratory infection. On examination she was found to have clinical signs of Right Middle Lobe pneumonia and was found to be weak, especially in her proximal muscle groups. She had bilateral ptosis as well as facial weakness. She had active arthritis in multiple joints. Despite intravenous antibiotics and full supportive management she deteriorated rapidly, and within 12 hours required intubation and ventilation. The patient was found to have high ACH receptor antibodies and responded dramatically to pyridostygmine therapy, confirming the diagnosis of MG. High prednisone and azathioprine have been added to her regime. Discussion: Myasthenia Gravis is a rare association with JIA. The majority of cases appear to be associated with oligo-articular JIA. This patient presented after an acute infection and a recent worsening in her JIA symptoms. DA - 2011 DB - OpenUCT DO - 10.1186/1546-0096-9-S1-P185 DP - University of Cape Town J1 - Pediatric Rheumatology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis TI - MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis UR - http://hdl.handle.net/11427/15067 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15067
dc.identifier.urihttp://dx.doi.org/10.1186/1546-0096-9-S1-P185
dc.identifier.vancouvercitationScott C, Kalla A. MyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritis. Pediatric Rheumatology. 2011; http://hdl.handle.net/11427/15067.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Rheumatologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Scott and Kalla; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourcePediatric Rheumatologyen_ZA
dc.source.urihttp://www.ped-rheum.com/en_ZA
dc.subject.otherMyasthenia Gravisen_ZA
dc.titleMyastheniaGravis(MG) in a patient with Juvenile Idiopathic Arthritisen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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