IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells

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dc.contributor.authorBesnard, Anne-Gaelleen_ZA
dc.contributor.authorGuabiraba, Rodrigoen_ZA
dc.contributor.authorNiedbala, Wandaen_ZA
dc.contributor.authorPalomo, Jenniferen_ZA
dc.contributor.authorReverchon, Floraen_ZA
dc.contributor.authorShaw, Tovah Nen_ZA
dc.contributor.authorCouper, Kevin Nen_ZA
dc.contributor.authorRyffel, Bernharden_ZA
dc.contributor.authorLiew, Foo Yen_ZA
dc.date.accessioned2016-01-02T05:05:42Z
dc.date.available2016-01-02T05:05:42Z
dc.date.issued2015en_ZA
dc.description.abstractAuthor Summary Cerebral malaria (CM) caused by the parasite Plasmodium sp . is a fatal disease, especially in children. Currently there is no effective treatment. We report here our investigation on the role of a recently discovered cytokine IL-33, in treating experimental cerebral malaria (ECM) in the susceptible C57BL/6 mice. IL-33 protects the mice against ECM. The protection is accompanied by a reduction of Th1 response and the enhancement of type 2 cytokine response. We also found that IL-33 mediates its protective effect by inducing a population of type 2 innate lymphoid cells (ILC2), which then polarize macrophages to alternatively-activated phenotypes (M2). M2 in turn expand regulatory T cells (Tregs) which suppress the deleterious Th1 response. Our report therefore reveals hitherto unrecognised mechanisms of the regulation of ECM and provide a novel function of IL-33.en_ZA
dc.identifier.apacitationBesnard, A., Guabiraba, R., Niedbala, W., Palomo, J., Reverchon, F., Shaw, T. N., ... Liew, F. Y. (2015). IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. <i>PLoS One</i>, http://hdl.handle.net/11427/16153en_ZA
dc.identifier.chicagocitationBesnard, Anne-Gaelle, Rodrigo Guabiraba, Wanda Niedbala, Jennifer Palomo, Flora Reverchon, Tovah N Shaw, Kevin N Couper, Bernhard Ryffel, and Foo Y Liew "IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells." <i>PLoS One</i> (2015) http://hdl.handle.net/11427/16153en_ZA
dc.identifier.citationBesnard, A. G., Guabiraba, R., Niedbala, W., Palomo, J., Reverchon, F., Shaw, T. N., ... & Liew, F. Y. (2015). IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog, 11(2), e1004607. doi:10.1371/journal.ppat.1004607en_ZA
dc.identifier.ris TY - Journal Article AU - Besnard, Anne-Gaelle AU - Guabiraba, Rodrigo AU - Niedbala, Wanda AU - Palomo, Jennifer AU - Reverchon, Flora AU - Shaw, Tovah N AU - Couper, Kevin N AU - Ryffel, Bernhard AU - Liew, Foo Y AB - Author Summary Cerebral malaria (CM) caused by the parasite Plasmodium sp . is a fatal disease, especially in children. Currently there is no effective treatment. We report here our investigation on the role of a recently discovered cytokine IL-33, in treating experimental cerebral malaria (ECM) in the susceptible C57BL/6 mice. IL-33 protects the mice against ECM. The protection is accompanied by a reduction of Th1 response and the enhancement of type 2 cytokine response. We also found that IL-33 mediates its protective effect by inducing a population of type 2 innate lymphoid cells (ILC2), which then polarize macrophages to alternatively-activated phenotypes (M2). M2 in turn expand regulatory T cells (Tregs) which suppress the deleterious Th1 response. Our report therefore reveals hitherto unrecognised mechanisms of the regulation of ECM and provide a novel function of IL-33. DA - 2015 DB - OpenUCT DO - 10.1371/journal.ppat.1004607 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells TI - IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells UR - http://hdl.handle.net/11427/16153 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16153
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1004607
dc.identifier.vancouvercitationBesnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, et al. IL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS One. 2015; http://hdl.handle.net/11427/16153.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2015 Besnard et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherMacrophagesen_ZA
dc.subject.otherCerebral malariaen_ZA
dc.subject.otherCytokinesen_ZA
dc.subject.otherRegulatory T cellsen_ZA
dc.subject.otherSpleenen_ZA
dc.subject.otherT cellsen_ZA
dc.subject.otherParasitemiaen_ZA
dc.subject.otherParasitic diseasesen_ZA
dc.titleIL-33-mediated protection against experimental cerebral malaria is linked to induction of Type 2 innate lymphoid cells, M2 macrophages and regulatory T cellsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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