Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base

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dc.contributor.authorMachingaidze, Shingai
dc.contributor.authorHussey, Gregory D
dc.contributor.authorWiysonge, Charles S
dc.date.accessioned2015-06-30T12:12:20Z
dc.date.available2015-06-30T12:12:20Z
dc.date.issued2014-02-04
dc.date.updated2015-01-15T17:58:12Z
dc.description.abstractAbstract Background Over the past four decades, extraordinary progress has been made in establishing and improving childhood immunization programmes around Africa. In order to ensure effective and sustainable positive growth of these childhood immunisations programmes, the development, adaptation and implementation of all interventions (programme activities, new vaccines, new strategies and policies) should be informed by the best available local evidence. Methods An assessment of the peer-reviewed literature on childhood immunization research published in English from 1970 to 2010 was conducted in PubMed and Africa-Wide databases. All study types were eligible for inclusion. A standard form was used to extract information from all studies identified as relevant and entered into a Microsoft Access database for analysis. Results Our initial search yielded 5436 articles from the two databases, from which 848 full text articles were identified as relevant. Among studies classified as clinical research (417), 40% were clinical trials, 24% were burden of disease/epidemiology and 36% were other clinical studies. Among studies classified as operational research (431), 77% related to programme management, 18% were policy related and 5% were related to vaccine financing. Studies were conducted in 48 African countries with six countries (South Africa, The Gambia, Nigeria, Senegal, Guinea-Bissau and Kenya) accounting for 56% of the total research output. Studies were published in 152 different journals with impact factors ranging from 0.192 to 53.29; with a median impact factor of 3.572. Conclusion A similar proportion of clinical versus operational research output was found. However, an uneven distribution across Africa was observed with only six countries accounting for over half of the research output. The research conducted was of moderate to high quality, with 62% being published in journals with 2010 impact factors greater than two. Urgent attention should be given to the development of research capacity in low performing countries around Africa, with increased focus on the process of turning immunisations programme research evidence into policy and practice, as well as increased focus on issues relating to vaccine financing and sustainability in Africa.
dc.identifier.apacitationMachingaidze, S., Hussey, G. D., & Wiysonge, C. S. (2014). Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base. <i>BMC Health Services Research</i>, http://hdl.handle.net/11427/13195en_ZA
dc.identifier.chicagocitationMachingaidze, Shingai, Gregory D Hussey, and Charles S Wiysonge "Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base." <i>BMC Health Services Research</i> (2014) http://hdl.handle.net/11427/13195en_ZA
dc.identifier.citationMachingaidze, S., Hussey, G. D., & Wiysonge, C. S. (2014). Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base. BMC health services research, 14(1), 52.
dc.identifier.ris TY - Journal Article AU - Machingaidze, Shingai AU - Hussey, Gregory D AU - Wiysonge, Charles S AB - Abstract Background Over the past four decades, extraordinary progress has been made in establishing and improving childhood immunization programmes around Africa. In order to ensure effective and sustainable positive growth of these childhood immunisations programmes, the development, adaptation and implementation of all interventions (programme activities, new vaccines, new strategies and policies) should be informed by the best available local evidence. Methods An assessment of the peer-reviewed literature on childhood immunization research published in English from 1970 to 2010 was conducted in PubMed and Africa-Wide databases. All study types were eligible for inclusion. A standard form was used to extract information from all studies identified as relevant and entered into a Microsoft Access database for analysis. Results Our initial search yielded 5436 articles from the two databases, from which 848 full text articles were identified as relevant. Among studies classified as clinical research (417), 40% were clinical trials, 24% were burden of disease/epidemiology and 36% were other clinical studies. Among studies classified as operational research (431), 77% related to programme management, 18% were policy related and 5% were related to vaccine financing. Studies were conducted in 48 African countries with six countries (South Africa, The Gambia, Nigeria, Senegal, Guinea-Bissau and Kenya) accounting for 56% of the total research output. Studies were published in 152 different journals with impact factors ranging from 0.192 to 53.29; with a median impact factor of 3.572. Conclusion A similar proportion of clinical versus operational research output was found. However, an uneven distribution across Africa was observed with only six countries accounting for over half of the research output. The research conducted was of moderate to high quality, with 62% being published in journals with 2010 impact factors greater than two. Urgent attention should be given to the development of research capacity in low performing countries around Africa, with increased focus on the process of turning immunisations programme research evidence into policy and practice, as well as increased focus on issues relating to vaccine financing and sustainability in Africa. DA - 2014-02-04 DB - OpenUCT DO - 10.1186/1472-6963-14-52 DP - University of Cape Town J1 - BMC Health Services Research LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base TI - Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base UR - http://hdl.handle.net/11427/13195 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13195
dc.identifier.urihttp://dx.doi.org/10.1186/1472-6963-14-52
dc.identifier.vancouvercitationMachingaidze S, Hussey GD, Wiysonge CS. Trends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base. BMC Health Services Research. 2014; http://hdl.handle.net/11427/13195.en_ZA
dc.language.rfc3066en
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderMachingaidze et al.; licensee BioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/2.0*
dc.sourceBMC Health Services Researchen_ZA
dc.source.urihttp://www.biomedcentral.com/bmchealthservres/
dc.subject.otherExpanded Programme on Immunisations (EPI)en_ZA
dc.subject.otherImmunisations programmesen_ZA
dc.subject.otherChildhood immunisationsen_ZA
dc.titleTrends in the types and quality of childhood immunisations research output from Africa 1970–2010: mapping the evidence base
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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