Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry
| dc.contributor.author | Hume, Struan | |
| dc.contributor.author | Tshimanga, Jean-Marc Ilunga | |
| dc.contributor.author | Geoghegan, Patrick | |
| dc.contributor.author | Malan, Arnaud G | |
| dc.contributor.author | Ho, Wei Hua | |
| dc.contributor.author | Ngoepe, Malebogo N | |
| dc.date.accessioned | 2022-04-06T08:46:48Z | |
| dc.date.available | 2022-04-06T08:46:48Z | |
| dc.date.issued | 2022-01-11 | |
| dc.date.updated | 2022-01-20T15:24:34Z | |
| dc.description.abstract | Computational models of cerebral aneurysm thrombosis are designed for use in research and clinical applications. A steady flow assumption is applied in many of these models. To explore the accuracy of this assumption a pulsatile-flow thrombin-transport computational fluid dynamics (CFD) model, which uses a symmetrical idealized aneurysm geometry, was developed. First, a steady-flow computational model was developed and validated using data from an in vitro experiment, based on particle image velocimetry (PIV). The experimental data revealed an asymmetric flow pattern in the aneurysm. The validated computational model was subsequently altered to incorporate pulsatility, by applying a data-derived flow function at the inlet boundary. For both the steady and pulsatile computational models, a scalar function simulating thrombin generation was applied at the aneurysm wall. To determine the influence of pulsatility on thrombin transport, the outputs of the steady model were compared to the outputs of the pulsatile model. The comparison revealed that in the pulsatile case, an average of 10.2% less thrombin accumulates within the aneurysm than the steady case for any given time, due to periodic losses of a significant amount of thrombin-concentrated blood from the aneurysm into the parent vessel’s bloodstream. These findings demonstrate that pulsatility may change clotting outcomes in cerebral aneurysms. | en_US |
| dc.identifier | doi: 10.3390/sym14010133 | |
| dc.identifier.apacitation | Hume, S., Tshimanga, J. I., Geoghegan, P., Malan, A. G., Ho, W. H., & Ngoepe, M. N. (2022). Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry. <i>Symmetry</i>, 14(1), 133. http://hdl.handle.net/11427/36280 | en_ZA |
| dc.identifier.chicagocitation | Hume, Struan, Jean-Marc Ilunga Tshimanga, Patrick Geoghegan, Arnaud G Malan, Wei Hua Ho, and Malebogo N Ngoepe "Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry." <i>Symmetry</i> 14, 1. (2022): 133. http://hdl.handle.net/11427/36280 | en_ZA |
| dc.identifier.citation | Hume, S., Tshimanga, J.I., Geoghegan, P., Malan, A.G., Ho, W.H. & Ngoepe, M.N. 2022. Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry. <i>Symmetry.</i> 14(1):133. http://hdl.handle.net/11427/36280 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Hume, Struan AU - Tshimanga, Jean-Marc Ilunga AU - Geoghegan, Patrick AU - Malan, Arnaud G AU - Ho, Wei Hua AU - Ngoepe, Malebogo N AB - Computational models of cerebral aneurysm thrombosis are designed for use in research and clinical applications. A steady flow assumption is applied in many of these models. To explore the accuracy of this assumption a pulsatile-flow thrombin-transport computational fluid dynamics (CFD) model, which uses a symmetrical idealized aneurysm geometry, was developed. First, a steady-flow computational model was developed and validated using data from an in vitro experiment, based on particle image velocimetry (PIV). The experimental data revealed an asymmetric flow pattern in the aneurysm. The validated computational model was subsequently altered to incorporate pulsatility, by applying a data-derived flow function at the inlet boundary. For both the steady and pulsatile computational models, a scalar function simulating thrombin generation was applied at the aneurysm wall. To determine the influence of pulsatility on thrombin transport, the outputs of the steady model were compared to the outputs of the pulsatile model. The comparison revealed that in the pulsatile case, an average of 10.2% less thrombin accumulates within the aneurysm than the steady case for any given time, due to periodic losses of a significant amount of thrombin-concentrated blood from the aneurysm into the parent vessel’s bloodstream. These findings demonstrate that pulsatility may change clotting outcomes in cerebral aneurysms. DA - 2022-01-11 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Symmetry KW - intracranial aneurysm KW - thrombosis KW - pulsatile flow KW - CFD KW - PIV LK - https://open.uct.ac.za PY - 2022 T1 - Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry TI - Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry UR - http://hdl.handle.net/11427/36280 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/36280 | |
| dc.identifier.vancouvercitation | Hume S, Tshimanga JI, Geoghegan P, Malan AG, Ho WH, Ngoepe MN. Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry. Symmetry. 2022;14(1):133. http://hdl.handle.net/11427/36280. | en_ZA |
| dc.language.iso | en | en_US |
| dc.publisher.department | Department of Mechanical Engineering | en_US |
| dc.publisher.faculty | Faculty of Engineering and the Built Environment | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Symmetry | en_US |
| dc.source.journalissue | 1 | en_US |
| dc.source.journalvolume | 14 | en_US |
| dc.source.pagination | 133 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/symmetry | |
| dc.subject | intracranial aneurysm | |
| dc.subject | thrombosis | |
| dc.subject | pulsatile flow | |
| dc.subject | CFD | |
| dc.subject | PIV | |
| dc.title | Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry | en_US |
| dc.type | Journal Article | en_US |