Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study

Simple item page
dc.contributor.authorRadcliffe, M
dc.contributor.authorMeÿer, M
dc.contributor.authorRoditi, D
dc.contributor.authorMalan, A
dc.date.accessioned2021-10-08T07:17:53Z
dc.date.available2021-10-08T07:17:53Z
dc.date.issued1997
dc.description.abstractOBJECTIVE: To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis. DESIGN: Randomised study comparing benzathine penicillin with no therapy. SETTING: Peninsula Maternal and Neonatal Service, Cape Town. SUBJECTS: Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more. OUTCOME MEASURES: The number of cases of congenital syphilis was determined by results of IgM Western blots and follow-up VDRL titres. RESULTS AND CONCLUSIONS: Of 8 patients followed up in the non-treatment group, 4 had congenital syphilis while 0/11 had the disease (P = 0.035) in the group receiving benzathine penicillin. Although the exact failure rate is unknown, benzathine penicillin is effective in preventing symptomatic congenital syphilis when administered to high-risk newborns.
dc.identifier.apacitationRadcliffe, M., Meÿer, M., Roditi, D., & Malan, A. (1997). Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study. <i>South African Medical Journal</i>, 87(1), 62 - 625. http://hdl.handle.net/11427/34853en_ZA
dc.identifier.chicagocitationRadcliffe, M, M Meÿer, D Roditi, and A Malan "Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study." <i>South African Medical Journal</i> 87, 1. (1997): 62 - 625. http://hdl.handle.net/11427/34853en_ZA
dc.identifier.citationRadcliffe, M., Meÿer, M., Roditi, D. & Malan, A. 1997. Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study. <i>South African Medical Journal.</i> 87(1):62 - 625. http://hdl.handle.net/11427/34853en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Radcliffe, M AU - Meÿer, M AU - Roditi, D AU - Malan, A AB - OBJECTIVE: To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis. DESIGN: Randomised study comparing benzathine penicillin with no therapy. SETTING: Peninsula Maternal and Neonatal Service, Cape Town. SUBJECTS: Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more. OUTCOME MEASURES: The number of cases of congenital syphilis was determined by results of IgM Western blots and follow-up VDRL titres. RESULTS AND CONCLUSIONS: Of 8 patients followed up in the non-treatment group, 4 had congenital syphilis while 0/11 had the disease (P = 0.035) in the group receiving benzathine penicillin. Although the exact failure rate is unknown, benzathine penicillin is effective in preventing symptomatic congenital syphilis when administered to high-risk newborns. DA - 1997 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 1997 SM - 0038-2469 T1 - Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study TI - Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study UR - http://hdl.handle.net/11427/34853 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34853
dc.identifier.vancouvercitationRadcliffe M, Meÿer M, Roditi D, Malan A. Single-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study. South African Medical Journal. 1997;87(1):62 - 625. http://hdl.handle.net/11427/34853.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue1
dc.source.journalvolume87
dc.source.pagination62 - 625
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherSyphilis
dc.subject.otherCongenital
dc.subject.otherRisk factor
dc.subject.otherPrevention
dc.subject.otherChemoprophylaxis
dc.subject.otherSingle dose
dc.subject.otherBenzathine benzylpenicillin
dc.subject.otherInfant
dc.subject.otherEfficiency
dc.subject.otherSouth Africa
dc.subject.otherTreponematosis
dc.subject.otherSpirachaetosis
dc.subject.otherBacteriosis
dc.subject.otherInfection
dc.subject.otherHuman
dc.subject.otherAfrica
dc.subject.otherCongénital
dc.subject.otherFacteur risque
dc.subject.otherPrévention
dc.subject.otherChimioprophylaxie
dc.subject.otherDose unique
dc.subject.otherBenzathine benzylpénicilline
dc.titleSingle-dose benzathine penicillin in infants at risk of congenital syphilis : results of a randomised study
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
RadcliffeM_Single_dose_ben_1997.pdf
Size:
1.76 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles