Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition

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dc.contributor.authorWillis, Jesse R
dc.contributor.authorGonzález-Torres, Pedro
dc.contributor.authorPittis, Alexandros A
dc.contributor.authorBejarano, Luis A
dc.contributor.authorCozzuto, Luca
dc.contributor.authorAndreu-Somavilla, Nuria
dc.contributor.authorAlloza-Trabado, Miriam
dc.contributor.authorValentín, Antonia
dc.contributor.authorKsiezopolska, Ewa
dc.contributor.authorCompany, Carlos
dc.contributor.authorOnywera, Harris
dc.contributor.authorMontfort, Magda
dc.contributor.authorHermoso, Antonio
dc.contributor.authorIraola-Guzmán, Susana
dc.contributor.authorSaus, Ester
dc.contributor.authorLabeeuw, Annick
dc.contributor.authorCarolis, Carlo
dc.contributor.authorHecht, Jochen
dc.contributor.authorPonomarenko, Julia
dc.contributor.authorGabaldón, Toni
dc.date.accessioned2018-12-11T14:08:59Z
dc.date.available2018-12-11T14:08:59Z
dc.date.issued2018-12-06
dc.date.updated2018-12-09T04:40:17Z
dc.description.abstractAbstract Background The oral cavity comprises a rich and diverse microbiome, which plays important roles in health and disease. Previous studies have mostly focused on adult populations or in very young children, whereas the adolescent oral microbiome remains poorly studied. Here, we used a citizen science approach and 16S profiling to assess the oral microbiome of 1500 adolescents around Spain and its relationships with lifestyle, diet, hygiene, and socioeconomic and environmental parameters. Results Our results provide a detailed snapshot of the adolescent oral microbiome and how it varies with lifestyle and other factors. In addition to hygiene and dietary habits, we found that the composition of tap water was related to important changes in the abundance of several bacterial genera. This points to an important role of drinking water in shaping the oral microbiota, which has been so far poorly explored. Overall, the microbiome samples of our study can be clustered into two broad compositional patterns (stomatotypes), driven mostly by Neisseria and Prevotella, respectively. These patterns show striking similarities with those found in unrelated populations. Conclusions We hypothesize that these stomatotypes represent two possible global optimal equilibria in the oral microbiome that reflect underlying constraints of the human oral niche. As such, they should be found across a variety of geographical regions, lifestyles, and ages.
dc.identifier.apacitationWillis, J. R., González-Torres, P., Pittis, A. A., Bejarano, L. A., Cozzuto, L., Andreu-Somavilla, N., ... Gabaldón, T. (2018). Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition. http://hdl.handle.net/11427/29137en_ZA
dc.identifier.chicagocitationWillis, Jesse R, Pedro González-Torres, Alexandros A Pittis, Luis A Bejarano, Luca Cozzuto, Nuria Andreu-Somavilla, Miriam Alloza-Trabado, et al "Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition." (2018) http://hdl.handle.net/11427/29137en_ZA
dc.identifier.citationMicrobiome. 2018 Dec 06;6(1):218
dc.identifier.ris TY - Journal Article AU - Willis, Jesse R AU - González-Torres, Pedro AU - Pittis, Alexandros A AU - Bejarano, Luis A AU - Cozzuto, Luca AU - Andreu-Somavilla, Nuria AU - Alloza-Trabado, Miriam AU - Valentín, Antonia AU - Ksiezopolska, Ewa AU - Company, Carlos AU - Onywera, Harris AU - Montfort, Magda AU - Hermoso, Antonio AU - Iraola-Guzmán, Susana AU - Saus, Ester AU - Labeeuw, Annick AU - Carolis, Carlo AU - Hecht, Jochen AU - Ponomarenko, Julia AU - Gabaldón, Toni AB - Abstract Background The oral cavity comprises a rich and diverse microbiome, which plays important roles in health and disease. Previous studies have mostly focused on adult populations or in very young children, whereas the adolescent oral microbiome remains poorly studied. Here, we used a citizen science approach and 16S profiling to assess the oral microbiome of 1500 adolescents around Spain and its relationships with lifestyle, diet, hygiene, and socioeconomic and environmental parameters. Results Our results provide a detailed snapshot of the adolescent oral microbiome and how it varies with lifestyle and other factors. In addition to hygiene and dietary habits, we found that the composition of tap water was related to important changes in the abundance of several bacterial genera. This points to an important role of drinking water in shaping the oral microbiota, which has been so far poorly explored. Overall, the microbiome samples of our study can be clustered into two broad compositional patterns (stomatotypes), driven mostly by Neisseria and Prevotella, respectively. These patterns show striking similarities with those found in unrelated populations. Conclusions We hypothesize that these stomatotypes represent two possible global optimal equilibria in the oral microbiome that reflect underlying constraints of the human oral niche. As such, they should be found across a variety of geographical regions, lifestyles, and ages. DA - 2018-12-06 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PY - 2018 T1 - Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition TI - Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition UR - http://hdl.handle.net/11427/29137 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s40168-018-0592-3
dc.identifier.urihttp://hdl.handle.net/11427/29137
dc.identifier.vancouvercitationWillis JR, González-Torres P, Pittis AA, Bejarano LA, Cozzuto L, Andreu-Somavilla N, et al. Citizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition. 2018; http://hdl.handle.net/11427/29137.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.rights.holderThe Author(s).
dc.subject.otherOral microbiome
dc.subject.otherMetagenomics
dc.subject.otherStomatotypes
dc.subject.otherTap water composition
dc.titleCitizen science charts two major “stomatotypes” in the oral microbiome of adolescents and reveals links with habits and drinking water composition
dc.typeJournal Article
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