Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes

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dc.contributor.advisorThilo, Lutzen_ZA
dc.contributor.authorStroud, Evelyn Joyen_ZA
dc.date.accessioned2018-01-29T07:08:23Z
dc.date.available2018-01-29T07:08:23Z
dc.date.issued1995en_ZA
dc.description.abstractThe present study was undertaken to establish the mechanism(s) involved in the endocytic pathway, in particular, early endosome processing and delivery to the lysosomes. Two models for endosome processing have previously been proposed in the literature, namely the maturation and vesicular traffic models. The general consensus has been an early phase of intermingling of the endocytic contents markers within early endosomes that mature to form non-fusogenic late endosomes (maturation model). This maturation phase is followed by a segregation phase where intermingling of contents between vesicles no longer takes place. To establish the mechanism(s) involved in early endosome processing and delivery to lysosomes, a kinetic analysis was made using results from cellular fluid-phase uptake assays. This unique approach offers an alternative view to previous studies on the mechanisms in operation during endocytic processing. The results and conclusions made could thus confirm or disprove previously proposed mechanisms.en_ZA
dc.identifier.apacitationStroud, E. J. (1995). <i>Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry & Structural Biology. Retrieved from http://hdl.handle.net/11427/27043en_ZA
dc.identifier.chicagocitationStroud, Evelyn Joy. <i>"Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry & Structural Biology, 1995. http://hdl.handle.net/11427/27043en_ZA
dc.identifier.citationStroud, E. 1995. Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Stroud, Evelyn Joy AB - The present study was undertaken to establish the mechanism(s) involved in the endocytic pathway, in particular, early endosome processing and delivery to the lysosomes. Two models for endosome processing have previously been proposed in the literature, namely the maturation and vesicular traffic models. The general consensus has been an early phase of intermingling of the endocytic contents markers within early endosomes that mature to form non-fusogenic late endosomes (maturation model). This maturation phase is followed by a segregation phase where intermingling of contents between vesicles no longer takes place. To establish the mechanism(s) involved in early endosome processing and delivery to lysosomes, a kinetic analysis was made using results from cellular fluid-phase uptake assays. This unique approach offers an alternative view to previous studies on the mechanisms in operation during endocytic processing. The results and conclusions made could thus confirm or disprove previously proposed mechanisms. DA - 1995 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1995 T1 - Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes TI - Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes UR - http://hdl.handle.net/11427/27043 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27043
dc.identifier.vancouvercitationStroud EJ. Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry & Structural Biology, 1995 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27043en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistry and Structural Biology
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.subject.otherBiological transporten_ZA
dc.subject.otherEndosomesen_ZA
dc.subject.otherLysosomesen_ZA
dc.titleKinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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