An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia

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dc.contributor.advisorLesosky, Maia
dc.contributor.authorAuckloo, Marie Belle Kathrina Mendoza
dc.date.accessioned2023-02-23T10:30:43Z
dc.date.available2023-02-23T10:30:43Z
dc.date.issued2022
dc.date.updated2023-02-20T12:13:49Z
dc.description.abstractGlobally, pneumonia is a leading cause of morbidity and mortality in children younger than the age of 5 years, especially in low- and middle-income countries. The aetiology of paediatric pneumonia is complex, and its definitive determination remains challenging. S. pneumoniae, H. influenzae, M. catarrhalis, and S. aureus are among the most frequent bacterial causes of childhood pneumonia. Common to such recognised bacterial pathogens is the occurrence of asymptomatic bacterial colonisation or carriage of the nasopharynx, which in turn precedes disease development and progression. This study investigates the trends and patterns of bacterial carriage in the development of pneumonia in South African infants up to one year of life. It is hypothesised that respiratory bacterial carriage is considerably influenced by age and seasonality. Based on previously collected time-series data from the Drakenstein Child Health Study conducted in Paarl, South Africa, this study focuses on exploring the effects of season on nasopharyngeal carriage of pathogens occurring in the nasopharynx of young children with and without the occurrence of lower respiratory tract infection. Using logistic mixed effects models and taking into account the repeated measure structure of the data as well as seasonal components, we found that seasonal variations occur in the prevalence of nasopharyngeal carriage of respiratory pathogens in infants, with and without lower respiratory tract infection. With the inclusion of age-effects, these associations appeared to be highly complex. Understanding the factors that influence bacterial carriage, asymptomatic or not, is necessary to better understand the opportunities for and impact of intervention strategies against lower respiratory tract illness.
dc.identifier.apacitationAuckloo, M. B. K. M. (2022). <i>An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia</i>. (). ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/37021en_ZA
dc.identifier.chicagocitationAuckloo, Marie Belle Kathrina Mendoza. <i>"An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia."</i> ., ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022. http://hdl.handle.net/11427/37021en_ZA
dc.identifier.citationAuckloo, M.B.K.M. 2022. An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia. . ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. http://hdl.handle.net/11427/37021en_ZA
dc.identifier.ris TY - Master Thesis AU - Auckloo, Marie Belle Kathrina Mendoza AB - Globally, pneumonia is a leading cause of morbidity and mortality in children younger than the age of 5 years, especially in low- and middle-income countries. The aetiology of paediatric pneumonia is complex, and its definitive determination remains challenging. S. pneumoniae, H. influenzae, M. catarrhalis, and S. aureus are among the most frequent bacterial causes of childhood pneumonia. Common to such recognised bacterial pathogens is the occurrence of asymptomatic bacterial colonisation or carriage of the nasopharynx, which in turn precedes disease development and progression. This study investigates the trends and patterns of bacterial carriage in the development of pneumonia in South African infants up to one year of life. It is hypothesised that respiratory bacterial carriage is considerably influenced by age and seasonality. Based on previously collected time-series data from the Drakenstein Child Health Study conducted in Paarl, South Africa, this study focuses on exploring the effects of season on nasopharyngeal carriage of pathogens occurring in the nasopharynx of young children with and without the occurrence of lower respiratory tract infection. Using logistic mixed effects models and taking into account the repeated measure structure of the data as well as seasonal components, we found that seasonal variations occur in the prevalence of nasopharyngeal carriage of respiratory pathogens in infants, with and without lower respiratory tract infection. With the inclusion of age-effects, these associations appeared to be highly complex. Understanding the factors that influence bacterial carriage, asymptomatic or not, is necessary to better understand the opportunities for and impact of intervention strategies against lower respiratory tract illness. DA - 2022_ DB - OpenUCT DP - University of Cape Town KW - Public Health LK - https://open.uct.ac.za PY - 2022 T1 - An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia TI - An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia UR - http://hdl.handle.net/11427/37021 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/37021
dc.identifier.vancouvercitationAuckloo MBKM. An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia. []. ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/37021en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Public Health and Family Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.subjectPublic Health
dc.titleAn investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMPH
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