Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise

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dc.contributor.authorWest, Sacha J
dc.contributor.authorGoedecke, Julia H
dc.contributor.authorVan Niekerk, Lizl
dc.contributor.authorCollins, Malcolm
dc.contributor.authorSt Clair Gibson, Alan
dc.contributor.authorMacDonald, Ian A
dc.contributor.authorNoakes, Timothy D
dc.contributor.authorLambert, Estelle V
dc.date.accessioned2017-12-01T09:50:10Z
dc.date.available2017-12-01T09:50:10Z
dc.date.issued2005
dc.date.updated2017-11-09T07:36:45Z
dc.description.abstractThe aim of this study was to differentiate the role of raised plasma adrenaline (Adr) concentrations from sympathoadrenal activation associated with moderate-intensity exercise, on muscle activation, cardiopulmonary responses, fuel metabolism, and ratings of perceived exertion (RPE) during low-intensity exercise. Two groups of subjects (MOD, n=6; LOW, n=7) cycled on two occasions for 90 min. MOD cycled at 68% VO2max with saline infusion, and at 34% VO2max with Adr infusion. LOW cycled twice at 34% VO2max, with either Adr or saline infusion. Infusions (0.015 g Adr/kg/min) started at 15 min and increased plasma [Adr] somewhat higher than during exercise at 68% VO2max (~1.9 vs. 1.4 nM, at 75 min). Mean plasma glucose and lactate concentrations during LOW were significantly higher with Adr than saline infusion (5.1±0.6 vs. 4.4±0.3 mmol/l, P<0.01 and 2.1±0.8 vs. 1.3±0.5 mmol/l, P<0.01, respectively). Elevated [Adr], without increased exercise intensity, did not alter glycogenolysis. There were also no effects of Adr infusion at 34% VO2max on heart rate, oxygen consumption, [FFA], respiratory exchange ratio, intramuscular triglyceride utilization, muscle activation or RPE. In conclusion, elevated [Adr] similar to those found during moderate-intensity exercise increased plasma glucose and lactate availability, but did not alter intramuscular fuel utilization, effort perception or muscle activation.
dc.identifierhttp://dx.doi.org/DOI 10.1007/s00424-005-1516-1
dc.identifier.apacitationWest, S. J., Goedecke, J. H., Van Niekerk, L., Collins, M., St Clair Gibson, A., MacDonald, I. A., ... Lambert, E. V. (2005). Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise. <i>European Journal of Physiology</i>, http://hdl.handle.net/11427/26437en_ZA
dc.identifier.chicagocitationWest, Sacha J, Julia H Goedecke, Lizl Van Niekerk, Malcolm Collins, Alan St Clair Gibson, Ian A MacDonald, Timothy D Noakes, and Estelle V Lambert "Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise." <i>European Journal of Physiology</i> (2005) http://hdl.handle.net/11427/26437en_ZA
dc.identifier.citationWest, S. J., Goedecke, J. H., Van Niekerk, L., Collins, M., Gibson, A. S. C., Macdonald, I. A., ... & Lambert, E. V. (2006). Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise. Pflügers Archiv, 451(6), 727-737.
dc.identifier.ris TY - AU - West, Sacha J AU - Goedecke, Julia H AU - Van Niekerk, Lizl AU - Collins, Malcolm AU - St Clair Gibson, Alan AU - MacDonald, Ian A AU - Noakes, Timothy D AU - Lambert, Estelle V AB - The aim of this study was to differentiate the role of raised plasma adrenaline (Adr) concentrations from sympathoadrenal activation associated with moderate-intensity exercise, on muscle activation, cardiopulmonary responses, fuel metabolism, and ratings of perceived exertion (RPE) during low-intensity exercise. Two groups of subjects (MOD, n=6; LOW, n=7) cycled on two occasions for 90 min. MOD cycled at 68% VO2max with saline infusion, and at 34% VO2max with Adr infusion. LOW cycled twice at 34% VO2max, with either Adr or saline infusion. Infusions (0.015 g Adr/kg/min) started at 15 min and increased plasma [Adr] somewhat higher than during exercise at 68% VO2max (~1.9 vs. 1.4 nM, at 75 min). Mean plasma glucose and lactate concentrations during LOW were significantly higher with Adr than saline infusion (5.1±0.6 vs. 4.4±0.3 mmol/l, P<0.01 and 2.1±0.8 vs. 1.3±0.5 mmol/l, P<0.01, respectively). Elevated [Adr], without increased exercise intensity, did not alter glycogenolysis. There were also no effects of Adr infusion at 34% VO2max on heart rate, oxygen consumption, [FFA], respiratory exchange ratio, intramuscular triglyceride utilization, muscle activation or RPE. In conclusion, elevated [Adr] similar to those found during moderate-intensity exercise increased plasma glucose and lactate availability, but did not alter intramuscular fuel utilization, effort perception or muscle activation. DA - 2005 DB - OpenUCT DP - University of Cape Town J1 - European Journal of Physiology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise TI - Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise UR - http://hdl.handle.net/11427/26437 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26437
dc.identifier.vancouvercitationWest SJ, Goedecke JH, Van Niekerk L, Collins M, St Clair Gibson A, MacDonald IA, et al. Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise. European Journal of Physiology. 2005; http://hdl.handle.net/11427/26437.en_ZA
dc.language.isoeng
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceEuropean Journal of Physiology
dc.source.urihttps://link.springer.com/journal/424
dc.subject.otherElectromyographic activity
dc.subject.otherIntramuscular triglyceride
dc.titleEffects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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