The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study

Simple item page
dc.contributor.advisorCombrinck, MIen_ZA
dc.contributor.authorMahne, Anna Ceciliaen_ZA
dc.date.accessioned2015-01-15T11:26:43Z
dc.date.available2015-01-15T11:26:43Z
dc.date.issued2010en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 113-135).en_ZA
dc.description.abstractTwenty percent of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a debilitating sUb-cortical dementia. HIV-related cognitive impairment is a primary neurological complication of HIV infection, as opposed to neurological diseases secondary to opportunistic infections in the immune compromised host. Our study investigated the role of systemic markers of inflammation and oxidative stress, inflammatory changes in the brain on magnetic resonance spectroscopy (MRS) and the role of the APOE E4 allele in HIV-associated dementia (HAD) in a South African population. We hypothesized that cognitive impairment and brain inflammation would correlate with systemic markers of inflammation and oxidative stress; with an inverse relation to anti-oxidant capacity.en_ZA
dc.identifier.apacitationMahne, A. C. (2010). <i>The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery. Retrieved from http://hdl.handle.net/11427/12218en_ZA
dc.identifier.chicagocitationMahne, Anna Cecilia. <i>"The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery, 2010. http://hdl.handle.net/11427/12218en_ZA
dc.identifier.citationMahne, A. 2010. The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mahne, Anna Cecilia AB - Twenty percent of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a debilitating sUb-cortical dementia. HIV-related cognitive impairment is a primary neurological complication of HIV infection, as opposed to neurological diseases secondary to opportunistic infections in the immune compromised host. Our study investigated the role of systemic markers of inflammation and oxidative stress, inflammatory changes in the brain on magnetic resonance spectroscopy (MRS) and the role of the APOE E4 allele in HIV-associated dementia (HAD) in a South African population. We hypothesized that cognitive impairment and brain inflammation would correlate with systemic markers of inflammation and oxidative stress; with an inverse relation to anti-oxidant capacity. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study TI - The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study UR - http://hdl.handle.net/11427/12218 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12218
dc.identifier.vancouvercitationMahne AC. The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12218en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Neurosurgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleThe role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2010_mahne_a_c_opd.pdf
Size:
5.88 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters