An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam.

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dc.contributor.advisorKidson, Sen_ZA
dc.contributor.authorGoolam, Mohammed Mubeenen_ZA
dc.date.accessioned2014-07-29T09:03:39Z
dc.date.available2014-07-29T09:03:39Z
dc.date.issued2012en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe principle aim of this study was to derive an in vitro model that could be used to study corneal endothelial development. This was done by investigating methods to induce a mesenchymal-to-epithelial transition (MET) in mouse periocular mesenchyme cells to drive them to form fully differentiated adult corneal endothelial cells in culture. Periocular mesenchyme surrounding the optic cup was dissected from E12.5 and E13.5 mouse embryos and immortalised with the SV40 large T-antigen. Two cell lines were thus derived and named E12.5POM and E13.5POM respectively.en_ZA
dc.identifier.apacitationGoolam, M. M. (2012). <i>An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3391en_ZA
dc.identifier.chicagocitationGoolam, Mohammed Mubeen. <i>"An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012. http://hdl.handle.net/11427/3391en_ZA
dc.identifier.citationGoolam, M. 2012. An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Goolam, Mohammed Mubeen AB - The principle aim of this study was to derive an in vitro model that could be used to study corneal endothelial development. This was done by investigating methods to induce a mesenchymal-to-epithelial transition (MET) in mouse periocular mesenchyme cells to drive them to form fully differentiated adult corneal endothelial cells in culture. Periocular mesenchyme surrounding the optic cup was dissected from E12.5 and E13.5 mouse embryos and immortalised with the SV40 large T-antigen. Two cell lines were thus derived and named E12.5POM and E13.5POM respectively. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam TI - An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam UR - http://hdl.handle.net/11427/3391 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3391
dc.identifier.vancouvercitationGoolam MM. An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3391en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleAn in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam.en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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