The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure
| dc.contributor.advisor | Bernon, Marc | |
| dc.contributor.advisor | Jonas, Eduard | |
| dc.contributor.author | Soldati, Vuyolwethu Sonwabile | |
| dc.date.accessioned | 2023-04-20T13:26:07Z | |
| dc.date.available | 2023-04-20T13:26:07Z | |
| dc.date.issued | 2022 | |
| dc.date.updated | 2023-04-20T13:25:47Z | |
| dc.description.abstract | Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have evaluated serial post-operative lactate and liver function tests (LFT) to predict PHLF. Aim: This study evaluated the prognostic utility of serial lactate concentrations and LFTs to predict PHLF following hepatectomy. Methods: All major liver resections (≥ 3 Couinaud segments) undertaken at Groote Schuur Hospital and UCT Private Academic Hospital from May 2018 to April 2021 were included. Lactate levels were measured 4-hourly for the first 24 hours post hepatectomy and daily LFTs for the first 5 days. Associations between baseline patient characteristics and lactate dynamics in PHLF as well as the predictive value of lactate, INR and bilirubin were determined. Results: Forty-seven patients, mean age 56.5 (±13.2) years, of whom 24 were males were assessed. Five (10.6%) patients had PHLF and were older (67.4 ± 12.2) and were predominantly men (80%)... | |
| dc.identifier.apacitation | Soldati, V. S. (2022). <i>The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure</i>. (). ,Faculty of Health Sciences ,Division of General Surgery. Retrieved from http://hdl.handle.net/11427/37799 | en_ZA |
| dc.identifier.chicagocitation | Soldati, Vuyolwethu Sonwabile. <i>"The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure."</i> ., ,Faculty of Health Sciences ,Division of General Surgery, 2022. http://hdl.handle.net/11427/37799 | en_ZA |
| dc.identifier.citation | Soldati, V.S. 2022. The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure. . ,Faculty of Health Sciences ,Division of General Surgery. http://hdl.handle.net/11427/37799 | en_ZA |
| dc.identifier.ris | TY - Master Thesis AU - Soldati, Vuyolwethu Sonwabile AB - Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have evaluated serial post-operative lactate and liver function tests (LFT) to predict PHLF. Aim: This study evaluated the prognostic utility of serial lactate concentrations and LFTs to predict PHLF following hepatectomy. Methods: All major liver resections (≥ 3 Couinaud segments) undertaken at Groote Schuur Hospital and UCT Private Academic Hospital from May 2018 to April 2021 were included. Lactate levels were measured 4-hourly for the first 24 hours post hepatectomy and daily LFTs for the first 5 days. Associations between baseline patient characteristics and lactate dynamics in PHLF as well as the predictive value of lactate, INR and bilirubin were determined. Results: Forty-seven patients, mean age 56.5 (±13.2) years, of whom 24 were males were assessed. Five (10.6%) patients had PHLF and were older (67.4 ± 12.2) and were predominantly men (80%)... DA - 2022 DB - OpenUCT DP - University of Cape Town KW - general surgery LK - https://open.uct.ac.za PY - 2022 T1 - The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure TI - The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure UR - http://hdl.handle.net/11427/37799 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/37799 | |
| dc.identifier.vancouvercitation | Soldati VS. The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure. []. ,Faculty of Health Sciences ,Division of General Surgery, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/37799 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Division of General Surgery | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | general surgery | |
| dc.title | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |