The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination

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dc.contributor.advisorHanekom, Willem Aen_ZA
dc.contributor.authorDube, Fredericken_ZA
dc.date.accessioned2014-12-28T14:55:44Z
dc.date.available2014-12-28T14:55:44Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (leaves 102-114).en_ZA
dc.description.abstractBacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants.en_ZA
dc.identifier.apacitationDube, F. (2010). <i>The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/10377en_ZA
dc.identifier.chicagocitationDube, Frederick. <i>"The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2010. http://hdl.handle.net/11427/10377en_ZA
dc.identifier.citationDube, F. 2010. The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dube, Frederick AB - Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination TI - The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination UR - http://hdl.handle.net/11427/10377 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10377
dc.identifier.vancouvercitationDube F. The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10377en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleThe effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccinationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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