Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis

Simple item page
dc.contributor.authorWood, Robin
dc.contributor.authorLawn, Stephen D
dc.contributor.authorBekker, Linda-Gail
dc.date.accessioned2018-05-08T10:39:04Z
dc.date.available2018-05-08T10:39:04Z
dc.date.issued2009
dc.date.updated2016-01-22T07:57:03Z
dc.description.abstractGolub et al. [1] recently reported a retrospective analysis of rates of incident tuberculosis (TB) in a large observational cohort of 2778 patients accessing HIV care in rural and urban South Africa. The TB incidence rate was highest [7.1/100 person-years; 95% confidence interval (CI)¼ 6.2–8.2] during the period of care when patients did not receive isoniazid preventive therapy (IPT) or highly active antiretroviral therapy (HAART). The rates were lower during person-time that accrued throughout follow-up after initiation of IPT (5.2/100 person-years; 95% CI¼ 3.4–7.8) and throughout follow-up on HAART alone (4.6/100 person-years, 95% CI¼ 3.4– 6.2). The rate was lower still (1.1/100 person-years 95% CI¼ 0.2–7.6) during person-time accrued during sequential IPT and HAART (IPTþ HAART). The authors concluded that TB risk was significantly reduced by IPT in HAART-treated adults. It was further concluded that ‘the dramatic reduction in TB risk’ demonstrated in this study together with supportive data from a similarly analysed study from Brazil [2] indicates that widespread use 1444 AIDS 2009, Vol 23 No 11 Fig. 1. T2-weighted flair image demonstrating enhancing lesion in the right precentral gyrus. Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. of IPT should be implemented in conjunction with the roll-out of HAART.
dc.identifierhttp://dx.doi.org/10.1097/QAD.0b013e32832d53e7.
dc.identifier.apacitationWood, R., Lawn, S. D., & Bekker, L. (2009). Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis. <i>AIDS</i>, http://hdl.handle.net/11427/28008en_ZA
dc.identifier.chicagocitationWood, Robin, Stephen D Lawn, and Linda-Gail Bekker "Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis." <i>AIDS</i> (2009) http://hdl.handle.net/11427/28008en_ZA
dc.identifier.citationBekker, L. G., Lawn, S. D., & Wood, R. (2009). Are the effects of isoniazid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis?.
dc.identifier.ris TY - AU - Wood, Robin AU - Lawn, Stephen D AU - Bekker, Linda-Gail AB - Golub et al. [1] recently reported a retrospective analysis of rates of incident tuberculosis (TB) in a large observational cohort of 2778 patients accessing HIV care in rural and urban South Africa. The TB incidence rate was highest [7.1/100 person-years; 95% confidence interval (CI)¼ 6.2–8.2] during the period of care when patients did not receive isoniazid preventive therapy (IPT) or highly active antiretroviral therapy (HAART). The rates were lower during person-time that accrued throughout follow-up after initiation of IPT (5.2/100 person-years; 95% CI¼ 3.4–7.8) and throughout follow-up on HAART alone (4.6/100 person-years, 95% CI¼ 3.4– 6.2). The rate was lower still (1.1/100 person-years 95% CI¼ 0.2–7.6) during person-time accrued during sequential IPT and HAART (IPTþ HAART). The authors concluded that TB risk was significantly reduced by IPT in HAART-treated adults. It was further concluded that ‘the dramatic reduction in TB risk’ demonstrated in this study together with supportive data from a similarly analysed study from Brazil [2] indicates that widespread use 1444 AIDS 2009, Vol 23 No 11 Fig. 1. T2-weighted flair image demonstrating enhancing lesion in the right precentral gyrus. Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. of IPT should be implemented in conjunction with the roll-out of HAART. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - AIDS LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis TI - Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis UR - http://hdl.handle.net/11427/28008 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/28008
dc.identifier.vancouvercitationWood R, Lawn SD, Bekker L. Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis. AIDS. 2009; http://hdl.handle.net/11427/28008.en_ZA
dc.language.isoeng
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceAIDS
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/19564724
dc.subject.otherAIDS-Related Opportunistic Infections
dc.subject.otherAntitubercular Agents
dc.subject.otherEpidemiologic Methods
dc.subject.otherHighly Active Antiretroviral Therapy
dc.subject.otherHumans
dc.subject.otherIsoniazid
dc.subject.otherTuberculosis
dc.titleAre the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis
dc.typeJournal Article
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bekker_Are_effects_isoniaid_2009.pdf
Size:
24.03 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles