Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study

Simple item page
dc.contributor.authorMadhi, Shabir A.
dc.contributor.authorKwatra, Gaurav
dc.contributor.authorMyers, Jonathan E.
dc.contributor.authorJassat, Waasila
dc.contributor.authorDhar, Nisha
dc.contributor.authorMukendi, Christian K.
dc.contributor.authorBlumberg, Lucille
dc.contributor.authorWelch, Richard
dc.contributor.authorIzu, Alane
dc.contributor.authorMutevedzi, Portia C.
dc.date.accessioned2024-04-29T10:32:07Z
dc.date.available2024-04-29T10:32:07Z
dc.date.issued2023-02-21
dc.date.updated2023-03-28T12:56:46Z
dc.description.abstractWe conducted an epidemiologic survey to determine the seroprevalence of SARS-CoV-2 anti-nucleocapsid (anti-N) and anti-spike (anti-S) protein IgG from 1 March to 11 April 2022 after the BA.1-dominant wave had subsided in South Africa and prior to another wave dominated by the BA.4 and BA.5 (BA.4/BA.5) sub-lineages. We also analysed epidemiologic trends in Gauteng Province for cases, hospitalizations, recorded deaths, and excess deaths were evaluated from the inception of the pandemic through 17 November 2022. Despite only 26.7% (1995/7470) of individuals having received a COVID-19 vaccine, the overall seropositivity for SARS-CoV-2 was 90.9% (95% confidence interval (CI), 90.2 to 91.5) at the end of the BA.1 wave, and 64% (95% CI, 61.8 to 65.9) of individuals were infected during the BA.1-dominant wave. The SARS-CoV-2 infection fatality risk was 16.5–22.3 times lower in the BA.1-dominant wave compared with the pre-BA.1 waves for recorded deaths (0.02% vs. 0.33%) and estimated excess mortality (0.03% vs. 0.67%). Although there are ongoing cases of COVID-19 infections, hospitalization and death, there has not been any meaningful resurgence of COVID-19 since the BA.1-dominant wave despite only 37.8% coverage by at least a single dose of COVID-19 vaccine in Gauteng, South Africa.
dc.identifier.apacitationMadhi, Shabir A., Kwatra, G., Myers, Jonathan E., Jassat, W., Dhar, N., Mukendi, Christian K., ... Mutevedzi, Portia C. (2023). Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study. <i>Viruses</i>, 15(3), 597. http://hdl.handle.net/11427/39494en_ZA
dc.identifier.chicagocitationMadhi, Shabir A., Gaurav Kwatra, Jonathan E. Myers, Waasila Jassat, Nisha Dhar, Christian K. Mukendi, Lucille Blumberg, Richard Welch, Alane Izu, and Portia C. Mutevedzi "Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study." <i>Viruses</i> 15, 3. (2023): 597. http://hdl.handle.net/11427/39494en_ZA
dc.identifier.citationMadhi, Shabir A., Kwatra, G., Myers, Jonathan E., Jassat, W., Dhar, N., Mukendi, Christian K., Blumberg, L. & Welch, R. et al. 2023. Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study. <i>Viruses.</i> 15(3):597. http://hdl.handle.net/11427/39494en_ZA
dc.identifier.ris TY - Journal Article AU - Madhi, Shabir A. AU - Kwatra, Gaurav AU - Myers, Jonathan E. AU - Jassat, Waasila AU - Dhar, Nisha AU - Mukendi, Christian K. AU - Blumberg, Lucille AU - Welch, Richard AU - Izu, Alane AU - Mutevedzi, Portia C. AB - We conducted an epidemiologic survey to determine the seroprevalence of SARS-CoV-2 anti-nucleocapsid (anti-N) and anti-spike (anti-S) protein IgG from 1 March to 11 April 2022 after the BA.1-dominant wave had subsided in South Africa and prior to another wave dominated by the BA.4 and BA.5 (BA.4/BA.5) sub-lineages. We also analysed epidemiologic trends in Gauteng Province for cases, hospitalizations, recorded deaths, and excess deaths were evaluated from the inception of the pandemic through 17 November 2022. Despite only 26.7% (1995/7470) of individuals having received a COVID-19 vaccine, the overall seropositivity for SARS-CoV-2 was 90.9% (95% confidence interval (CI), 90.2 to 91.5) at the end of the BA.1 wave, and 64% (95% CI, 61.8 to 65.9) of individuals were infected during the BA.1-dominant wave. The SARS-CoV-2 infection fatality risk was 16.5&ndash;22.3 times lower in the BA.1-dominant wave compared with the pre-BA.1 waves for recorded deaths (0.02% vs. 0.33%) and estimated excess mortality (0.03% vs. 0.67%). Although there are ongoing cases of COVID-19 infections, hospitalization and death, there has not been any meaningful resurgence of COVID-19 since the BA.1-dominant wave despite only 37.8% coverage by at least a single dose of COVID-19 vaccine in Gauteng, South Africa. DA - 2023-02-21 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PY - 2023 T1 - Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study TI - Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study UR - http://hdl.handle.net/11427/39494 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/39494
dc.identifier.urihttps://doi.org/10.3390/v15030597
dc.identifier.vancouvercitationMadhi Shabir A, Kwatra G, Myers Jonathan E, Jassat W, Dhar N, Mukendi Christian K, et al. Sustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study. Viruses. 2023;15(3):597. http://hdl.handle.net/11427/39494.en_ZA
dc.publisherMultidisciplinary Digital Publishing Institute
dc.sourceViruses
dc.source.journalissue3
dc.source.journalvolume15
dc.source.pagination597
dc.source.urihttps://www.mdpi.com/journal/viruses
dc.titleSustained Low Incidence of Severe and Fatal COVID-19 Following Widespread Infection Induced Immunity after the Omicron (BA.1) Dominant in Gauteng, South Africa: An Observational Study
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
viruses-15-00597-v2.pdf
Size:
1.25 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles