Proteoglycan genes and anterior cruciate ligament injury susceptibility
dc.contributor.advisor | September, Alison | en_ZA |
dc.contributor.advisor | Collins, Malcolm | en_ZA |
dc.contributor.author | Mannion, Sasha | en_ZA |
dc.date.accessioned | 2014-08-22T10:37:01Z | |
dc.date.available | 2014-08-22T10:37:01Z | |
dc.date.issued | 2013 | en_ZA |
dc.description | Includes abstract. | en_ZA |
dc.description | Includes bibliographical references. | en_ZA |
dc.description.abstract | Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility. | en_ZA |
dc.identifier.apacitation | Mannion, S. (2013). <i>Proteoglycan genes and anterior cruciate ligament injury susceptibility</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics. Retrieved from http://hdl.handle.net/11427/6670 | en_ZA |
dc.identifier.chicagocitation | Mannion, Sasha. <i>"Proteoglycan genes and anterior cruciate ligament injury susceptibility."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013. http://hdl.handle.net/11427/6670 | en_ZA |
dc.identifier.citation | Mannion, S. 2013. Proteoglycan genes and anterior cruciate ligament injury susceptibility. University of Cape Town. | en_ZA |
dc.identifier.ris | TY - Thesis / Dissertation AU - Mannion, Sasha AB - Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Proteoglycan genes and anterior cruciate ligament injury susceptibility TI - Proteoglycan genes and anterior cruciate ligament injury susceptibility UR - http://hdl.handle.net/11427/6670 ER - | en_ZA |
dc.identifier.uri | http://hdl.handle.net/11427/6670 | |
dc.identifier.vancouvercitation | Mannion S. Proteoglycan genes and anterior cruciate ligament injury susceptibility. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6670 | en_ZA |
dc.language.iso | eng | en_ZA |
dc.publisher.department | Division of Human Genetics | en_ZA |
dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
dc.publisher.institution | University of Cape Town | |
dc.subject.other | Medicine | en_ZA |
dc.title | Proteoglycan genes and anterior cruciate ligament injury susceptibility | en_ZA |
dc.type | Master Thesis | |
dc.type.qualificationlevel | Masters | |
dc.type.qualificationname | MSc | en_ZA |
uct.type.filetype | Text | |
uct.type.filetype | Image | |
uct.type.publication | Research | en_ZA |
uct.type.resource | Thesis | en_ZA |
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