Proteoglycan genes and anterior cruciate ligament injury susceptibility

dc.contributor.advisorSeptember, Alisonen_ZA
dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.authorMannion, Sashaen_ZA
dc.date.accessioned2014-08-22T10:37:01Z
dc.date.available2014-08-22T10:37:01Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractGenetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility.en_ZA
dc.identifier.apacitationMannion, S. (2013). <i>Proteoglycan genes and anterior cruciate ligament injury susceptibility</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics. Retrieved from http://hdl.handle.net/11427/6670en_ZA
dc.identifier.chicagocitationMannion, Sasha. <i>"Proteoglycan genes and anterior cruciate ligament injury susceptibility."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013. http://hdl.handle.net/11427/6670en_ZA
dc.identifier.citationMannion, S. 2013. Proteoglycan genes and anterior cruciate ligament injury susceptibility. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mannion, Sasha AB - Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured controls. Genes encoding proteoglycans are therefore plausible candidates to be investigated for an association with ACL injury susceptibility. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Proteoglycan genes and anterior cruciate ligament injury susceptibility TI - Proteoglycan genes and anterior cruciate ligament injury susceptibility UR - http://hdl.handle.net/11427/6670 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6670
dc.identifier.vancouvercitationMannion S. Proteoglycan genes and anterior cruciate ligament injury susceptibility. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Human Genetics, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6670en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Human Geneticsen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleProteoglycan genes and anterior cruciate ligament injury susceptibilityen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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