Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy

Simple item page
dc.contributor.advisorWearne, Nen_ZA
dc.contributor.advisorRayner, Ben_ZA
dc.contributor.authorBorkum, Megan Saraen_ZA
dc.date.accessioned2016-06-02T08:41:59Z
dc.date.available2016-06-02T08:41:59Z
dc.date.issued2015en_ZA
dc.description.abstractIntroduction: Few studies have been done in South Africa to establish the extent of chronic kidney disease (CKD) in stable outpatients infected with the human immunodeficiency virus (HIV). Both HIV and the anteretroviral therapy (ART) used to treat HIV have been associated with abnormal metabolic profile, increased cardiovascular risk and renal disease1,2,3. Hypertension has been found to be common in HIV infected individuals, in European and American cohorts, with a prevalence ranging from 13- 34%2. Nocturnal blood pressure (BP) is superior to daytime or office BP as a predictor of cardiovascular disease4. However, the relationship between circadian BP patterns, measured via ambulatory blood pressure (ABP) monitoring, and HIV has never been documented in the South African HIV infected population. Individuals with an abnormal diurnal rhythm and a blunted nocturnal decline in systolic BP (SBP), i.e. ≤ 10%, are referred to as 'non- dippers' and have the highest risk of cardiovascular complications4. HIV itself has been associated with a non- dipping status and may play a role in the HIV related increase in cardiovascular risk5.en_ZA
dc.identifier.apacitationBorkum, M. S. (2015). <i>Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Nephrology and Hypertension. Retrieved from http://hdl.handle.net/11427/19881en_ZA
dc.identifier.chicagocitationBorkum, Megan Sara. <i>"Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Nephrology and Hypertension, 2015. http://hdl.handle.net/11427/19881en_ZA
dc.identifier.citationBorkum, M. 2015. Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Borkum, Megan Sara AB - Introduction: Few studies have been done in South Africa to establish the extent of chronic kidney disease (CKD) in stable outpatients infected with the human immunodeficiency virus (HIV). Both HIV and the anteretroviral therapy (ART) used to treat HIV have been associated with abnormal metabolic profile, increased cardiovascular risk and renal disease1,2,3. Hypertension has been found to be common in HIV infected individuals, in European and American cohorts, with a prevalence ranging from 13- 34%2. Nocturnal blood pressure (BP) is superior to daytime or office BP as a predictor of cardiovascular disease4. However, the relationship between circadian BP patterns, measured via ambulatory blood pressure (ABP) monitoring, and HIV has never been documented in the South African HIV infected population. Individuals with an abnormal diurnal rhythm and a blunted nocturnal decline in systolic BP (SBP), i.e. ≤ 10%, are referred to as 'non- dippers' and have the highest risk of cardiovascular complications4. HIV itself has been associated with a non- dipping status and may play a role in the HIV related increase in cardiovascular risk5. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy TI - Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy UR - http://hdl.handle.net/11427/19881 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19881
dc.identifier.vancouvercitationBorkum MS. Chronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Nephrology and Hypertension, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/19881en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Nephrology and Hypertensionen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleChronic kidney disease prevalence and ambulatory blood pressure profile in healthy HIV positive subjects pre and post anti-retroviral therapyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2015_borkum_megan_sara.pdf
Size:
524.85 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters