Phytodentistry in Africa: prospects for head and neck cancers

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dc.contributor.authorAdeola, Henry A
dc.contributor.authorSabiu, Saheed
dc.contributor.authorAruleba, Raphael T
dc.contributor.authorAdekiya, Tayo A
dc.contributor.authorAdefuye, Anthonio O
dc.contributor.authorAdefuye, Ogheneochuko J
dc.contributor.authorOyinloye, Babatunji E
dc.date.accessioned2021-10-12T09:34:34Z
dc.date.available2021-10-12T09:34:34Z
dc.date.issued2021-02-05
dc.date.updated2021-02-07T04:13:01Z
dc.description.abstractBackground Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Although, significant milestones have been achieved in the molecular dentistry field in the past decade, there remains a dearth of application of phytopharmacological innovation in personalized and targeted therapies for dental diseases. Main body From time immemorial, plant products have long been an integral aspect of dental practice ranging from chewing sticks/herbal kinds of toothpaste to dental/impression materials. The current era of precision medicine seeks to apply a multipronged molecular and bio-computational approaches to solve fundamental medical problems that have hitherto remained difficult. Remarkable changes in the molecular/omics era, have transformed empirical therapies into personalized/individualized ones. Furthermore, the combinatorial application and the widespread introduction of high-throughput molecular tools such as pharmacogenomics, phytopharmacology, metabolomics, mathematical modelling, and genetic engineering inter alia, has tremendously improved the diagnostic and therapeutic landscape of medicine. Additionally, the variable molecular epidemiology of diseases among different population and emerging molecular evidence warrants the use of customized novel theranostic techniques. Unfortunately, the footprint of such emerging application is sparse in dental diseases such as maxillofacial cancers. Conclusion Hence, this review seeks to evaluate the potential application of phytopharmacological approaches to head and neck cancers in a resource-limited environment, such as Africa.en_US
dc.identifier.apacitationAdeola, H. A., Sabiu, S., Aruleba, R. T., Adekiya, T. A., Adefuye, A. O., Adefuye, O. J., & Oyinloye, B. E. (2021). Phytodentistry in Africa: prospects for head and neck cancers. <i>Clinical Phytoscience</i>, 7(Article number: 17), http://hdl.handle.net/11427/35195en_ZA
dc.identifier.chicagocitationAdeola, Henry A, Saheed Sabiu, Raphael T Aruleba, Tayo A Adekiya, Anthonio O Adefuye, Ogheneochuko J Adefuye, and Babatunji E Oyinloye "Phytodentistry in Africa: prospects for head and neck cancers." <i>Clinical Phytoscience</i> 7, Article number: 17. (2021) http://hdl.handle.net/11427/35195en_ZA
dc.identifier.citationAdeola, H.A., Sabiu, S., Aruleba, R.T., Adekiya, T.A., Adefuye, A.O., Adefuye, O.J. & Oyinloye, B.E. 2021. Phytodentistry in Africa: prospects for head and neck cancers. <i>Clinical Phytoscience.</i> 7(Article number: 17) http://hdl.handle.net/11427/35195en_ZA
dc.identifier.ris TY - Journal Article AU - Adeola, Henry A AU - Sabiu, Saheed AU - Aruleba, Raphael T AU - Adekiya, Tayo A AU - Adefuye, Anthonio O AU - Adefuye, Ogheneochuko J AU - Oyinloye, Babatunji E AB - Background Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Although, significant milestones have been achieved in the molecular dentistry field in the past decade, there remains a dearth of application of phytopharmacological innovation in personalized and targeted therapies for dental diseases. Main body From time immemorial, plant products have long been an integral aspect of dental practice ranging from chewing sticks/herbal kinds of toothpaste to dental/impression materials. The current era of precision medicine seeks to apply a multipronged molecular and bio-computational approaches to solve fundamental medical problems that have hitherto remained difficult. Remarkable changes in the molecular/omics era, have transformed empirical therapies into personalized/individualized ones. Furthermore, the combinatorial application and the widespread introduction of high-throughput molecular tools such as pharmacogenomics, phytopharmacology, metabolomics, mathematical modelling, and genetic engineering inter alia, has tremendously improved the diagnostic and therapeutic landscape of medicine. Additionally, the variable molecular epidemiology of diseases among different population and emerging molecular evidence warrants the use of customized novel theranostic techniques. Unfortunately, the footprint of such emerging application is sparse in dental diseases such as maxillofacial cancers. Conclusion Hence, this review seeks to evaluate the potential application of phytopharmacological approaches to head and neck cancers in a resource-limited environment, such as Africa. DA - 2021-02-05 DB - OpenUCT DP - University of Cape Town IS - Article number: 17 J1 - Clinical Phytoscience KW - Phytopharmacology KW - Cancer KW - Dental pathology KW - Molecular mechanism KW - Dentistry KW - Structural biology KW - Phytodentistry LK - https://open.uct.ac.za PY - 2021 T1 - Phytodentistry in Africa: prospects for head and neck cancers TI - Phytodentistry in Africa: prospects for head and neck cancers UR - http://hdl.handle.net/11427/35195 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s40816-021-00254-8
dc.identifier.urihttp://hdl.handle.net/11427/35195
dc.identifier.vancouvercitationAdeola HA, Sabiu S, Aruleba RT, Adekiya TA, Adefuye AO, Adefuye OJ, et al. Phytodentistry in Africa: prospects for head and neck cancers. Clinical Phytoscience. 2021;7(Article number: 17) http://hdl.handle.net/11427/35195.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceClinical Phytoscienceen_US
dc.source.journalissueArticle number: 17en_US
dc.source.journalvolume7en_US
dc.source.urihttps://clinphytoscience.springeropen.com/
dc.subjectPhytopharmacologyen_US
dc.subjectCanceren_US
dc.subjectDental pathologyen_US
dc.subjectMolecular mechanismen_US
dc.subjectDentistryen_US
dc.subjectStructural biologyen_US
dc.subjectPhytodentistryen_US
dc.titlePhytodentistry in Africa: prospects for head and neck cancersen_US
dc.typeJournal Articleen_US
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