Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms

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dc.contributor.authorIsmail, W I W
dc.contributor.authorKing, J A
dc.contributor.authorPillay, T S
dc.date.accessioned2017-06-26T10:45:10Z
dc.date.available2017-06-26T10:45:10Z
dc.date.issued2009
dc.date.updated2016-01-11T09:15:38Z
dc.description.abstractThe increase in incidence of HIV infection continues to be a major public health problem across the world, but more especially in sub-Saharan Africa. Treatment with highly active antiretroviral therapy (HAART) has improved the prognosis of patients with AIDS, but it has also increased the incidence of various metabolic disorders, in particular insulin resistance accompanied by dyslipidaemia, hyperglycaemia and lipodystrophy. This is often accompanied by frank type 2 diabetes and increased mortality from cardiovascular disease. It is important to understand the mechanistic basis for these side-effects as the incidence of these is likely to increase as the rollout of antiretroviral drugs continues.
dc.identifier.apacitationIsmail, W. I. W., King, J. A., & Pillay, T. S. (2009). Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms. <i>Journal of Endocrinology Metabolism and diabetes of South Africa (JEMDSA)</i>, http://hdl.handle.net/11427/24639en_ZA
dc.identifier.chicagocitationIsmail, W I W, J A King, and T S Pillay "Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms." <i>Journal of Endocrinology Metabolism and diabetes of South Africa (JEMDSA)</i> (2009) http://hdl.handle.net/11427/24639en_ZA
dc.identifier.citationIsmail, W. I. W., King, J. A., & Pillay, T. S. (2009). Insulin resistance induced by antiretroviral drugs: current understanding of molecular mechanisms: review article. Journal of Endocrinology, Metabolism and Diabetes in South Africa, 14(3), 129-132.
dc.identifier.ris TY - Journal Article AU - Ismail, W I W AU - King, J A AU - Pillay, T S AB - The increase in incidence of HIV infection continues to be a major public health problem across the world, but more especially in sub-Saharan Africa. Treatment with highly active antiretroviral therapy (HAART) has improved the prognosis of patients with AIDS, but it has also increased the incidence of various metabolic disorders, in particular insulin resistance accompanied by dyslipidaemia, hyperglycaemia and lipodystrophy. This is often accompanied by frank type 2 diabetes and increased mortality from cardiovascular disease. It is important to understand the mechanistic basis for these side-effects as the incidence of these is likely to increase as the rollout of antiretroviral drugs continues. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - Journal of Endocrinology Metabolism and diabetes of South Africa (JEMDSA) LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms TI - Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms UR - http://hdl.handle.net/11427/24639 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24639
dc.identifier.vancouvercitationIsmail WIW, King JA, Pillay TS. Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms. Journal of Endocrinology Metabolism and diabetes of South Africa (JEMDSA). 2009; http://hdl.handle.net/11427/24639.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Chemical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceJournal of Endocrinology Metabolism and diabetes of South Africa (JEMDSA)
dc.source.urihttp://www.jemdsa.co.za/index.php/JEMDSA
dc.subject.otherHIV protease inhibitors
dc.subject.otherInsulin resistance
dc.subject.otherInsulin signalling pathway
dc.titleInsulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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