Resistance to antimicrobial agents in bifidobacteria

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dc.contributor.advisorAbratt, Valerie Roseen_ZA
dc.contributor.advisorReid, Sharon Jen_ZA
dc.contributor.authorPrice, Claire Emileen_ZA
dc.date.accessioned2014-07-30T17:41:42Z
dc.date.available2014-07-30T17:41:42Z
dc.date.issued2005en_ZA
dc.descriptionIncludes bibliographical references (leaves 95-106).
dc.description.abstractFor bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts. Another aspect which should be studied is the safety of the probiotic bacterium and risks of acquisition of genes for resistance to antimicrobial agents. Although bifidobacteria exhibit resistance to a wide range of antibiotics, little is known about the molecular basis for this resistance. The aim of this project was, therefore, to investigate the molecular mechanisms responsible for the resistance to antibiotics and bile salts observed in bifidobacteria, and more specifically, to determine whether efflux systems are involved in this resistance. Five Bifidobacterium spp. were exposed to a range of antimicrobial agents. These included ethidium bromide, the bile salt sodium glycocholate, and a range of antibiotics.en_ZA
dc.identifier.apacitationPrice, C. E. (2005). <i>Resistance to antimicrobial agents in bifidobacteria</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/4323en_ZA
dc.identifier.chicagocitationPrice, Claire Emile. <i>"Resistance to antimicrobial agents in bifidobacteria."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2005. http://hdl.handle.net/11427/4323en_ZA
dc.identifier.citationPrice, C. 2005. Resistance to antimicrobial agents in bifidobacteria. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Price, Claire Emile AB - For bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts. Another aspect which should be studied is the safety of the probiotic bacterium and risks of acquisition of genes for resistance to antimicrobial agents. Although bifidobacteria exhibit resistance to a wide range of antibiotics, little is known about the molecular basis for this resistance. The aim of this project was, therefore, to investigate the molecular mechanisms responsible for the resistance to antibiotics and bile salts observed in bifidobacteria, and more specifically, to determine whether efflux systems are involved in this resistance. Five Bifidobacterium spp. were exposed to a range of antimicrobial agents. These included ethidium bromide, the bile salt sodium glycocholate, and a range of antibiotics. DA - 2005 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Resistance to antimicrobial agents in bifidobacteria TI - Resistance to antimicrobial agents in bifidobacteria UR - http://hdl.handle.net/11427/4323 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4323
dc.identifier.vancouvercitationPrice CE. Resistance to antimicrobial agents in bifidobacteria. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2005 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4323en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleResistance to antimicrobial agents in bifidobacteriaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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