Terpyridyl complexes as antimalarial agents

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dc.contributor.authorParaskevopoulosa, J N
dc.contributor.authorSmithc, P J
dc.contributor.authorHopped, H C
dc.contributor.authorChoprae, D
dc.contributor.authorGovender, T
dc.contributor.authorKrugera, H G
dc.contributor.authorMaguire, G E
dc.date.accessioned2016-05-17T13:28:22Z
dc.date.available2016-05-17T13:28:22Z
dc.date.issued2013
dc.date.updated2016-05-17T13:25:55Z
dc.description.abstractA number of transition metals and their terpyridyl complexes have been evaluated for antimalarial activity on the strain 3D7. The metals, ligands and complexes were each in turn investigated for their efficacy. All activities were in the sub-micromolar range (0.1-1 µM). Their modes of action were compared with that of chloroquine to discover whether or not they were capable of inhibiting haemozoin formation. The data indicate that efficacy could be a result of several mechanisms and that speciation of the metal complex and the manner in which the agents are added to the parasitic broth have a profound effect on the activity of the agents. We believe that our study offers a template by which other researchers should approach their experiments using transition metal complex agents.en_ZA
dc.identifier.apacitationParaskevopoulosa, J. N., Smithc, P. J., Hopped, H. C., Choprae, D., Govender, T., Krugera, H. G., & Maguire, G. E. (2013). Terpyridyl complexes as antimalarial agents. <i>South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie</i>, http://hdl.handle.net/11427/19703en_ZA
dc.identifier.chicagocitationParaskevopoulosa, J N, P J Smithc, H C Hopped, D Choprae, T Govender, H G Krugera, and G E Maguire "Terpyridyl complexes as antimalarial agents." <i>South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie</i> (2013) http://hdl.handle.net/11427/19703en_ZA
dc.identifier.citationParaskevopoulos, J. N., Smith, P. J., Hoppe, H. C., Chopra, D., Govender, T., Kruger, H. G., & Maguire, G. E. (2013). Terpyridyl complexes as antimalarial agents. South African Journal of Chemistry, 66, 80-85.en_ZA
dc.identifier.issn0379-4350en_ZA
dc.identifier.ris TY - Journal Article AU - Paraskevopoulosa, J N AU - Smithc, P J AU - Hopped, H C AU - Choprae, D AU - Govender, T AU - Krugera, H G AU - Maguire, G E AB - A number of transition metals and their terpyridyl complexes have been evaluated for antimalarial activity on the strain 3D7. The metals, ligands and complexes were each in turn investigated for their efficacy. All activities were in the sub-micromolar range (0.1-1 µM). Their modes of action were compared with that of chloroquine to discover whether or not they were capable of inhibiting haemozoin formation. The data indicate that efficacy could be a result of several mechanisms and that speciation of the metal complex and the manner in which the agents are added to the parasitic broth have a profound effect on the activity of the agents. We believe that our study offers a template by which other researchers should approach their experiments using transition metal complex agents. DA - 2013 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 SM - 0379-4350 T1 - Terpyridyl complexes as antimalarial agents TI - Terpyridyl complexes as antimalarial agents UR - http://hdl.handle.net/11427/19703 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19703
dc.identifier.vancouvercitationParaskevopoulosa JN, Smithc PJ, Hopped HC, Choprae D, Govender T, Krugera HG, et al. Terpyridyl complexes as antimalarial agents. South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie. 2013; http://hdl.handle.net/11427/19703.en_ZA
dc.languageengen_ZA
dc.publisherSouth African Chemical Instituteen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceSouth African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemieen_ZA
dc.source.urihttp://www.journals.co.za/sajchem/
dc.subject.otherantimalarial agents
dc.subject.otherterpyridyl and transition metals
dc.titleTerpyridyl complexes as antimalarial agentsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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