Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa

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dc.contributor.authorMatsha, Tandi Edithen_ZA
dc.contributor.authorMasconi, Katyaen_ZA
dc.contributor.authorYako, Yandiswa Yolandaen_ZA
dc.contributor.authorHassan, Mogamat Shaficken_ZA
dc.contributor.authorMacharia, Muiririen_ZA
dc.contributor.authorErasmus, Rajiv Timothyen_ZA
dc.contributor.authorKengne, Andre Pascalen_ZA
dc.date.accessioned2016-01-11T06:56:15Z
dc.date.available2016-01-11T06:56:15Z
dc.date.issued2012en_ZA
dc.description.abstractObjective: Though single nucleotide polymorphisms (SNPs) in the non-muscle myosin gene (MYH9) have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD), in African-Americans, some studies have also shown associations with diabetic end-stage renal disease. We investigated the association of MYH9 SNPs with renal traits in a mixed-ancestry South African population prone to diabetes. Research Design and METHODS: Three SNPs known to be associated with CKD (rs4821480, rs5756152 and rs12107) were genotyped using Taqman assay in 716 adults (198 with diabetes) from the Bellville-South community, Cape Town. Glomerular filtration rate was estimated (eGFR) and urinary albumin/creatinine ratio (ACR) assessed. Multivariable regressions were used to relate the SNPs with renal traits. RESULTS: Mean age was 53.6 years, with the expected differences observed in characteristics by diabetic status. Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p≤0.003), but not in non-diabetics (all p≥0.16), with significant interactions by diabetes status (interaction-p≤0.009). The association with ACR was borderline in diabetic participants (p = 0.05) and non-significant in non-diabetics (p = 0.85), with significant interaction (interaction p = 0.02). rs12107 was associated with fasting-, 2-hour glucose and HbA1c in diabetic participants only (interaction-p≤0.003), but not with renal traits. CONCLUSION: MYH9 SNPs were associated with renal traits only in diabetic participants in this population. Our findings and other studies suggest that MYH9 may have a broader genetic risk effect on kidney diseases.en_ZA
dc.identifier.apacitationMatsha, T. E., Masconi, K., Yako, Y. Y., Hassan, M. S., Macharia, M., Erasmus, R. T., & Kengne, A. P. (2012). Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16311en_ZA
dc.identifier.chicagocitationMatsha, Tandi Edith, Katya Masconi, Yandiswa Yolanda Yako, Mogamat Shafick Hassan, Muiriri Macharia, Rajiv Timothy Erasmus, and Andre Pascal Kengne "Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/16311en_ZA
dc.identifier.citationMatsha, T. E., Masconi, K., Yako, Y. Y., Hassan, M. S., Macharia, M., Erasmus, R. T., & Kengne, A. P. (2012). Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. PLoS ONE, 7(12). doi:10.1371/journal.pone.0052529en_ZA
dc.identifier.ris TY - Journal Article AU - Matsha, Tandi Edith AU - Masconi, Katya AU - Yako, Yandiswa Yolanda AU - Hassan, Mogamat Shafick AU - Macharia, Muiriri AU - Erasmus, Rajiv Timothy AU - Kengne, Andre Pascal AB - Objective: Though single nucleotide polymorphisms (SNPs) in the non-muscle myosin gene (MYH9) have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD), in African-Americans, some studies have also shown associations with diabetic end-stage renal disease. We investigated the association of MYH9 SNPs with renal traits in a mixed-ancestry South African population prone to diabetes. Research Design and METHODS: Three SNPs known to be associated with CKD (rs4821480, rs5756152 and rs12107) were genotyped using Taqman assay in 716 adults (198 with diabetes) from the Bellville-South community, Cape Town. Glomerular filtration rate was estimated (eGFR) and urinary albumin/creatinine ratio (ACR) assessed. Multivariable regressions were used to relate the SNPs with renal traits. RESULTS: Mean age was 53.6 years, with the expected differences observed in characteristics by diabetic status. Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p≤0.003), but not in non-diabetics (all p≥0.16), with significant interactions by diabetes status (interaction-p≤0.009). The association with ACR was borderline in diabetic participants (p = 0.05) and non-significant in non-diabetics (p = 0.85), with significant interaction (interaction p = 0.02). rs12107 was associated with fasting-, 2-hour glucose and HbA1c in diabetic participants only (interaction-p≤0.003), but not with renal traits. CONCLUSION: MYH9 SNPs were associated with renal traits only in diabetic participants in this population. Our findings and other studies suggest that MYH9 may have a broader genetic risk effect on kidney diseases. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0052529 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa TI - Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa UR - http://hdl.handle.net/11427/16311 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16311
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0052529
dc.identifier.vancouvercitationMatsha TE, Masconi K, Yako YY, Hassan MS, Macharia M, Erasmus RT, et al. Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. PLoS One. 2012; http://hdl.handle.net/11427/16311.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2012 Matsha et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherDiabetes mellitusen_ZA
dc.subject.otherChronic kidney diseaseen_ZA
dc.subject.otherType 2 diabetesen_ZA
dc.subject.otherCreatinineen_ZA
dc.subject.otherAlbuminsen_ZA
dc.subject.otherKidneysen_ZA
dc.subject.otherBlood pressureen_ZA
dc.subject.otherRenal diseasesen_ZA
dc.titlePolymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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