Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside

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dc.contributor.advisorNaidoo, Kevin Jen_ZA
dc.contributor.authorRogers, Ian Len_ZA
dc.date.accessioned2015-01-05T18:57:49Z
dc.date.available2015-01-05T18:57:49Z
dc.date.issued2011en_ZA
dc.description.abstractInfection by M. tuberculosis results in an estimated 1.7 million TB related deaths worldwide. Mycothiol is produced in M. tuberculosis as the dominant low molecular weight thiol and is thought to protect the bacteria against oxidative stress. Since mycothiol is unique to Actinomycetes and is also proposed to play an important role in the dormant state of Mycobacteria, the pseudo-dissacharide is seen as a potential target for novel anti-tuberculars. Targeting the mycothiol redox cycle has led to MshB inhibition by a series of substrate analogues. Kinetics studied showed that the competitive inhibition increased when the alkyl linker was lengthened. The binding of the inhibitors was investigated using computational techniques in order to rationalise the observed trend in inhibition.en_ZA
dc.identifier.apacitationRogers, I. L. (2011). <i>Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/11506en_ZA
dc.identifier.chicagocitationRogers, Ian L. <i>"Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011. http://hdl.handle.net/11427/11506en_ZA
dc.identifier.citationRogers, I. 2011. Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Rogers, Ian L AB - Infection by M. tuberculosis results in an estimated 1.7 million TB related deaths worldwide. Mycothiol is produced in M. tuberculosis as the dominant low molecular weight thiol and is thought to protect the bacteria against oxidative stress. Since mycothiol is unique to Actinomycetes and is also proposed to play an important role in the dormant state of Mycobacteria, the pseudo-dissacharide is seen as a potential target for novel anti-tuberculars. Targeting the mycothiol redox cycle has led to MshB inhibition by a series of substrate analogues. Kinetics studied showed that the competitive inhibition increased when the alkyl linker was lengthened. The binding of the inhibitors was investigated using computational techniques in order to rationalise the observed trend in inhibition. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside TI - Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside UR - http://hdl.handle.net/11427/11506 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11506
dc.identifier.vancouvercitationRogers IL. Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11506en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleRationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycosideen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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