Discovery of parvovirus-related sequences in an unexpected broad range of animals

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dc.contributor.authorFrançois, S
dc.contributor.authorFilloux, D
dc.contributor.authorRoumagnac, P
dc.contributor.authorBigot, D
dc.contributor.authorGayral, P
dc.contributor.authorMartin, D P
dc.contributor.authorFroissart, R
dc.contributor.authorOgliastro, M
dc.date.accessioned2021-10-08T07:16:02Z
dc.date.available2021-10-08T07:16:02Z
dc.date.issued2016
dc.description.abstractOur knowledge of the genetic diversity and host ranges of viruses is fragmentary. This is particularly true for the Parvoviridae family. Genetic diversity studies of single stranded DNA viruses within this family have been largely focused on arthropod- and vertebrate-infecting species that cause diseases of humans and our domesticated animals: a focus that has biased our perception of parvovirus diversity. While metagenomics approaches could help rectify this bias, so too could transcriptomics studies. Large amounts of transcriptomic data are available for a diverse array of animal species and whenever this data has inadvertently been gathered from virus-infected individuals, it could contain detectable viral transcripts. We therefore performed a systematic search for parvovirus-related sequences (PRSs) within publicly available transcript, genome and protein databases and eleven new transcriptome datasets. This revealed 463 PRSs in the transcript databases of 118 animals. At least 41 of these PRSs are likely integrated within animal genomes in that they were also found within genomic sequence databases. Besides illuminating the ubiquity of parvoviruses, the number of parvoviral sequences discovered within public databases revealed numerous previously unknown parvovirus-host combinations; particularly in invertebrates. Our findings suggest that the host-ranges of extant parvoviruses might span the entire animal kingdom.
dc.identifier.apacitationFrançois, S., Filloux, D., Roumagnac, P., Bigot, D., Gayral, P., Martin, D. P., ... Ogliastro, M. (2016). Discovery of parvovirus-related sequences in an unexpected broad range of animals. <i>Scientific Reports</i>, 6(1), 174 - 177. http://hdl.handle.net/11427/34752en_ZA
dc.identifier.chicagocitationFrançois, S, D Filloux, P Roumagnac, D Bigot, P Gayral, D P Martin, R Froissart, and M Ogliastro "Discovery of parvovirus-related sequences in an unexpected broad range of animals." <i>Scientific Reports</i> 6, 1. (2016): 174 - 177. http://hdl.handle.net/11427/34752en_ZA
dc.identifier.citationFrançois, S., Filloux, D., Roumagnac, P., Bigot, D., Gayral, P., Martin, D.P., Froissart, R. & Ogliastro, M. et al. 2016. Discovery of parvovirus-related sequences in an unexpected broad range of animals. <i>Scientific Reports.</i> 6(1):174 - 177. http://hdl.handle.net/11427/34752en_ZA
dc.identifier.issn2045-2322
dc.identifier.ris TY - Journal Article AU - François, S AU - Filloux, D AU - Roumagnac, P AU - Bigot, D AU - Gayral, P AU - Martin, D P AU - Froissart, R AU - Ogliastro, M AB - Our knowledge of the genetic diversity and host ranges of viruses is fragmentary. This is particularly true for the Parvoviridae family. Genetic diversity studies of single stranded DNA viruses within this family have been largely focused on arthropod- and vertebrate-infecting species that cause diseases of humans and our domesticated animals: a focus that has biased our perception of parvovirus diversity. While metagenomics approaches could help rectify this bias, so too could transcriptomics studies. Large amounts of transcriptomic data are available for a diverse array of animal species and whenever this data has inadvertently been gathered from virus-infected individuals, it could contain detectable viral transcripts. We therefore performed a systematic search for parvovirus-related sequences (PRSs) within publicly available transcript, genome and protein databases and eleven new transcriptome datasets. This revealed 463 PRSs in the transcript databases of 118 animals. At least 41 of these PRSs are likely integrated within animal genomes in that they were also found within genomic sequence databases. Besides illuminating the ubiquity of parvoviruses, the number of parvoviral sequences discovered within public databases revealed numerous previously unknown parvovirus-host combinations; particularly in invertebrates. Our findings suggest that the host-ranges of extant parvoviruses might span the entire animal kingdom. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Scientific Reports LK - https://open.uct.ac.za PY - 2016 SM - 2045-2322 T1 - Discovery of parvovirus-related sequences in an unexpected broad range of animals TI - Discovery of parvovirus-related sequences in an unexpected broad range of animals UR - http://hdl.handle.net/11427/34752 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34752
dc.identifier.vancouvercitationFrançois S, Filloux D, Roumagnac P, Bigot D, Gayral P, Martin DP, et al. Discovery of parvovirus-related sequences in an unexpected broad range of animals. Scientific Reports. 2016;6(1):174 - 177. http://hdl.handle.net/11427/34752.en_ZA
dc.language.isoeng
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceScientific Reports
dc.source.journalissue1
dc.source.journalvolume6
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1038/srep30880
dc.subject.otherAnimals
dc.subject.otherDatabases, Genetic
dc.subject.otherGene Expression Profiling
dc.subject.otherGenetic Variation
dc.subject.otherMetagenomics
dc.subject.otherParvovirus
dc.subject.otherPhylogeny
dc.subject.otherRNA, Viral
dc.subject.otherSequence Analysis, RNA
dc.subject.otherRNA, Viral
dc.titleDiscovery of parvovirus-related sequences in an unexpected broad range of animals
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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