A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains

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dc.contributor.authorChetty, Sen_ZA
dc.contributor.authorShephard, Een_ZA
dc.contributor.authorBowers, Den_ZA
dc.contributor.authorDarby, Men_ZA
dc.contributor.authorHorsnell, Wen_ZA
dc.contributor.authorChapman, Ren_ZA
dc.contributor.authorWilliamson, Aen_ZA
dc.date.accessioned2015-11-18T04:01:14Z
dc.date.available2015-11-18T04:01:14Z
dc.date.issued2012en_ZA
dc.description.abstractIn tuberculosis vaccine studies, perfingolysin expressing strains (pfo) of recombinant Mycobacterium bovis (rBCG) have been shown to enhance immunogenicity as compared to wildtype strains whilst pantothenate auxotrophic strains (ΔpanCD) have been shown to be safer and more immunogenic. Our group has recently shown that rBCGΔpanCD expressing HIV-1 Gag is more immunogenic than the wildtype Pasteur strain of BCG in the murine model. In this study, a wild type strain, a ΔpanCDstrain, a pfo strain and a ΔpanCD strain expressing perfringolysin (ΔpanCDpfo) of Danish BCG were used as vectors to express HIV-1 subtype C Gag. Gag specific immune responses induced by a prime with each rBCG-Gag vaccine and boost with modified vaccinia Ankara (MVA) were compared.en_ZA
dc.identifier.apacitationChetty, S., Shephard, E., Bowers, D., Darby, M., Horsnell, W., Chapman, R., & Williamson, A. (2012). A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains. <i>Retrovirology</i>, http://hdl.handle.net/11427/15094en_ZA
dc.identifier.chicagocitationChetty, S, E Shephard, D Bowers, M Darby, W Horsnell, R Chapman, and A Williamson "A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains." <i>Retrovirology</i> (2012) http://hdl.handle.net/11427/15094en_ZA
dc.identifier.citationChetty, S., Shephard, E., Bowers, D., Darby, M., Horsnell, W., Chapman, R., & Williamson, A. (2012). A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains. Retrovirology, 9(Suppl 2), P315.en_ZA
dc.identifier.ris TY - Journal Article AU - Chetty, S AU - Shephard, E AU - Bowers, D AU - Darby, M AU - Horsnell, W AU - Chapman, R AU - Williamson, A AB - In tuberculosis vaccine studies, perfingolysin expressing strains (pfo) of recombinant Mycobacterium bovis (rBCG) have been shown to enhance immunogenicity as compared to wildtype strains whilst pantothenate auxotrophic strains (ΔpanCD) have been shown to be safer and more immunogenic. Our group has recently shown that rBCGΔpanCD expressing HIV-1 Gag is more immunogenic than the wildtype Pasteur strain of BCG in the murine model. In this study, a wild type strain, a ΔpanCDstrain, a pfo strain and a ΔpanCD strain expressing perfringolysin (ΔpanCDpfo) of Danish BCG were used as vectors to express HIV-1 subtype C Gag. Gag specific immune responses induced by a prime with each rBCG-Gag vaccine and boost with modified vaccinia Ankara (MVA) were compared. DA - 2012 DB - OpenUCT DO - 10.1186/1742-4690-9-S2-P315 DP - University of Cape Town J1 - Retrovirology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains TI - A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains UR - http://hdl.handle.net/11427/15094 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15094
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-9-S2-P315
dc.identifier.vancouvercitationChetty S, Shephard E, Bowers D, Darby M, Horsnell W, Chapman R, et al. A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains. Retrovirology. 2012; http://hdl.handle.net/11427/15094.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Chetty et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRetrovirologyen_ZA
dc.source.urihttp://www.retrovirology.com/en_ZA
dc.subject.othertuberculosis vaccine studiesen_ZA
dc.subject.otherimmunogenicityen_ZA
dc.titleA pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strainsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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