The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy

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dc.contributor.advisorCoetzee, Nicolen_ZA
dc.contributor.advisorCoetzee, Gerriten_ZA
dc.contributor.authorGirdler-Brown, Brendan Vaughanen_ZA
dc.date.accessioned2018-01-29T07:15:44Z
dc.date.available2018-01-29T07:15:44Z
dc.date.issued1994en_ZA
dc.description.abstractThis dissertation reports the findings of a study which was carried out in the Cape Town City Council area, in order to establish whether the offering of rifampicin to household contacts, of patients with meningococcal disease, resulted in protection of those contacts against developing the disease during a 32 week follow up period. The study took the form of a retrospective follow up of 3 350 household contacts of 412 cases notified over a 4-year period (mid 1988-mid 1992). It was found that the offering of rifampicin to the household contacts resulted in an odds ratio of not developing meningococcal disease over the 32-week follow up period of 14, 17 (SD = 12, 34). Although there was a tendency for contacts who were not offered rifampicin to have been younger, and of male gender, when compared to those who were offered prophylaxis, these demographic differences were not statistically significant at the 0,05 level. Furthermore, three out of the four male second cases, all in the younger age group, were in fact offered prophylaxis. It seems desirable that prophylaxis should be given as soon as possible. It is concluded, therefore, that the offering of rifampicin to household contacts of patients with meningococcal disease, living under the prevailing social circumstances in the Western Cape, has protective benefit for those contacts. It is likely that the chemoprophylaxis programme prevented up to 88 cases of meningococcal disease over the study period of four years, as well as preventing 8 deaths from this disease, in the CCC population.en_ZA
dc.identifier.apacitationGirdler-Brown, B. V. (1994). <i>The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/27056en_ZA
dc.identifier.chicagocitationGirdler-Brown, Brendan Vaughan. <i>"The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 1994. http://hdl.handle.net/11427/27056en_ZA
dc.identifier.citationGirdler-Brown, B. 1994. The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Girdler-Brown, Brendan Vaughan AB - This dissertation reports the findings of a study which was carried out in the Cape Town City Council area, in order to establish whether the offering of rifampicin to household contacts, of patients with meningococcal disease, resulted in protection of those contacts against developing the disease during a 32 week follow up period. The study took the form of a retrospective follow up of 3 350 household contacts of 412 cases notified over a 4-year period (mid 1988-mid 1992). It was found that the offering of rifampicin to the household contacts resulted in an odds ratio of not developing meningococcal disease over the 32-week follow up period of 14, 17 (SD = 12, 34). Although there was a tendency for contacts who were not offered rifampicin to have been younger, and of male gender, when compared to those who were offered prophylaxis, these demographic differences were not statistically significant at the 0,05 level. Furthermore, three out of the four male second cases, all in the younger age group, were in fact offered prophylaxis. It seems desirable that prophylaxis should be given as soon as possible. It is concluded, therefore, that the offering of rifampicin to household contacts of patients with meningococcal disease, living under the prevailing social circumstances in the Western Cape, has protective benefit for those contacts. It is likely that the chemoprophylaxis programme prevented up to 88 cases of meningococcal disease over the study period of four years, as well as preventing 8 deaths from this disease, in the CCC population. DA - 1994 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1994 T1 - The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy TI - The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy UR - http://hdl.handle.net/11427/27056 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27056
dc.identifier.vancouvercitationGirdler-Brown BV. The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 1994 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27056en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCommunity Healthen_ZA
dc.subject.otherMeningococcal Infections - drug therapy - South Africaen_ZA
dc.subject.otherMeningococcal Infections - prevention and control - South Africaen_ZA
dc.subject.otherRifampin - therapeutic useen_ZA
dc.titleThe chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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