Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes

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dc.contributor.authorAttardo, Geoffrey M
dc.contributor.authorAbd-Alla, Adly M M
dc.contributor.authorAcosta-Serrano, Alvaro
dc.contributor.authorAllen, James E
dc.contributor.authorBateta, Rosemary
dc.contributor.authorBenoit, Joshua B
dc.contributor.authorBourtzis, Kostas
dc.contributor.authorCaers, Jelle
dc.contributor.authorCaljon, Guy
dc.contributor.authorChristensen, Mikkel B
dc.contributor.authorFarrow, David W
dc.contributor.authorFriedrich, Markus
dc.contributor.authorHua-Van, Aurélie
dc.contributor.authorJennings, Emily C
dc.contributor.authorLarkin, Denis M
dc.contributor.authorLawson, Daniel
dc.contributor.authorLehane, Michael J
dc.contributor.authorLenis, Vasileios P
dc.contributor.authorLowy-Gallego, Ernesto
dc.contributor.authorMacharia, Rosaline W
dc.contributor.authorMalacrida, Anna R
dc.contributor.authorMarco, Heather G
dc.contributor.authorMasiga, Daniel
dc.contributor.authorMaslen, Gareth L
dc.contributor.authorMatetovici, Irina
dc.contributor.authorMeisel, Richard P
dc.contributor.authorMeki, Irene
dc.contributor.authorMichalkova, Veronika
dc.contributor.authorMiller, Wolfgang J
dc.contributor.authorMinx, Patrick
dc.contributor.authorMireji, Paul O
dc.contributor.authorOmetto, Lino
dc.contributor.authorParker, Andrew G
dc.contributor.authorRio, Rita
dc.contributor.authorRose, Clair
dc.contributor.authorRosendale, Andrew J
dc.contributor.authorRota-Stabelli, Omar
dc.contributor.authorSavini, Grazia
dc.contributor.authorSchoofs, Liliane
dc.contributor.authorScolari, Francesca
dc.contributor.authorSwain, Martin T
dc.contributor.authorTakáč, Peter
dc.contributor.authorTomlinson, Chad
dc.contributor.authorTsiamis, George
dc.contributor.authorVan Den Abbeele, Jan
dc.contributor.authorVigneron, Aurelien
dc.contributor.authorWang, Jingwen
dc.contributor.authorWarren, Wesley C
dc.contributor.authorWaterhouse, Robert M
dc.contributor.authorWeirauch, Matthew T
dc.contributor.authorWeiss, Brian L
dc.contributor.authorWilson, Richard K
dc.contributor.authorZhao, Xin
dc.contributor.authorAksoy, Serap
dc.date.accessioned2019-10-10T09:32:45Z
dc.date.available2019-10-10T09:32:45Z
dc.date.issued2019-09-02
dc.date.updated2019-09-08T03:48:11Z
dc.description.abstractAbstract Background Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Results Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges. Conclusions Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
dc.identifier.apacitationAttardo, G. M., Abd-Alla, A. M. M., Acosta-Serrano, A., Allen, J. E., Bateta, R., Benoit, J. B., ... Aksoy, S. (2019). Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes. http://hdl.handle.net/11427/30570en_ZA
dc.identifier.chicagocitationAttardo, Geoffrey M, Adly M M Abd-Alla, Alvaro Acosta-Serrano, James E Allen, Rosemary Bateta, Joshua B Benoit, Kostas Bourtzis, et al "Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes." (2019) http://hdl.handle.net/11427/30570en_ZA
dc.identifier.citationGenome Biology. 2019 Sep 02;20(1):187
dc.identifier.ris TY - Journal Article AU - Attardo, Geoffrey M AU - Abd-Alla, Adly M M AU - Acosta-Serrano, Alvaro AU - Allen, James E AU - Bateta, Rosemary AU - Benoit, Joshua B AU - Bourtzis, Kostas AU - Caers, Jelle AU - Caljon, Guy AU - Christensen, Mikkel B AU - Farrow, David W AU - Friedrich, Markus AU - Hua-Van, Aurélie AU - Jennings, Emily C AU - Larkin, Denis M AU - Lawson, Daniel AU - Lehane, Michael J AU - Lenis, Vasileios P AU - Lowy-Gallego, Ernesto AU - Macharia, Rosaline W AU - Malacrida, Anna R AU - Marco, Heather G AU - Masiga, Daniel AU - Maslen, Gareth L AU - Matetovici, Irina AU - Meisel, Richard P AU - Meki, Irene AU - Michalkova, Veronika AU - Miller, Wolfgang J AU - Minx, Patrick AU - Mireji, Paul O AU - Ometto, Lino AU - Parker, Andrew G AU - Rio, Rita AU - Rose, Clair AU - Rosendale, Andrew J AU - Rota-Stabelli, Omar AU - Savini, Grazia AU - Schoofs, Liliane AU - Scolari, Francesca AU - Swain, Martin T AU - Takáč, Peter AU - Tomlinson, Chad AU - Tsiamis, George AU - Van Den Abbeele, Jan AU - Vigneron, Aurelien AU - Wang, Jingwen AU - Warren, Wesley C AU - Waterhouse, Robert M AU - Weirauch, Matthew T AU - Weiss, Brian L AU - Wilson, Richard K AU - Zhao, Xin AU - Aksoy, Serap AB - Abstract Background Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Results Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges. Conclusions Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies. DA - 2019-09-02 DB - OpenUCT DP - University of Cape Town KW - Tsetse KW - Trypanosomiasis KW - Hematophagy KW - Lactation KW - Disease KW - Neglected KW - Symbiosis LK - https://open.uct.ac.za PY - 2019 T1 - Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes TI - Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes UR - http://hdl.handle.net/11427/30570 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13059-019-1768-2
dc.identifier.urihttp://hdl.handle.net/11427/30570
dc.identifier.vancouvercitationAttardo GM, Abd-Alla AMM, Acosta-Serrano A, Allen JE, Bateta R, Benoit JB, et al. Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes. 2019; http://hdl.handle.net/11427/30570.en_ZA
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.subjectTsetse
dc.subjectTrypanosomiasis
dc.subjectHematophagy
dc.subjectLactation
dc.subjectDisease
dc.subjectNeglected
dc.subjectSymbiosis
dc.titleComparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
dc.typeJournal Article
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