Corpus callosum morphology in children on mid-sagittal MR imaging
| dc.contributor.advisor | Andronikou, Savvas | |
| dc.contributor.advisor | Kilborn,Tracy | |
| dc.contributor.author | Raubenheimer, Lauren | |
| dc.date.accessioned | 2019-02-19T13:45:26Z | |
| dc.date.available | 2019-02-19T13:45:26Z | |
| dc.date.issued | 2018 | |
| dc.date.updated | 2019-02-19T10:25:46Z | |
| dc.description.abstract | Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation. | |
| dc.identifier.apacitation | Raubenheimer, L. (2018). <i>Corpus callosum morphology in children on mid-sagittal MR imaging</i>. (). University of Cape Town ,Faculty of Health Sciences ,Division of Radiology. Retrieved from http://hdl.handle.net/11427/29692 | en_ZA |
| dc.identifier.chicagocitation | Raubenheimer, Lauren. <i>"Corpus callosum morphology in children on mid-sagittal MR imaging."</i> ., University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2018. http://hdl.handle.net/11427/29692 | en_ZA |
| dc.identifier.citation | Raubenheimer, L. 2018. Corpus callosum morphology in children on mid-sagittal MR imaging. University of Cape Town. | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Raubenheimer, Lauren AB - Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation. DA - 2018 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Corpus callosum morphology in children on mid-sagittal MR imaging TI - Corpus callosum morphology in children on mid-sagittal MR imaging UR - http://hdl.handle.net/11427/29692 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/29692 | |
| dc.identifier.vancouvercitation | Raubenheimer L. Corpus callosum morphology in children on mid-sagittal MR imaging. []. University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2018 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/29692 | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Division of Radiology | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject.other | Diagnostic Radiology | |
| dc.title | Corpus callosum morphology in children on mid-sagittal MR imaging | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationname | MMed |