Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.authorShabalala, Innocent Philanien_ZA
dc.date.accessioned2016-10-03T04:10:10Z
dc.date.available2016-10-03T04:10:10Z
dc.date.issued1995en_ZA
dc.description.abstractPseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG) and Differential Scanning Calorimetry (DSC) were used to investigate such thermal properties of the crystals as stabilities, desolvation processes and their kinetics as well as the melting of pure polymorphic forms of the drugs resulting from desolvation. Complementary studies of the compounds using X-ray powder diffraction (XRD) and DSC allowed identification and assignment of the products of desolvation i.e. polymorphs. Single crystal studies were carried out by X-ray diffraction methods. Interesting structural features such as crystal packing modes, hydrogen bonding schemes, cavity versus channel occupation by guest molecules and host conformations were investigated. From a high level of agreement of results obtained using these methods, the pseudopolymorphs and polymorphs studied were characterized unambiguously.en_ZA
dc.identifier.apacitationShabalala, I. P. (1995). <i>Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/22056en_ZA
dc.identifier.chicagocitationShabalala, Innocent Philani. <i>"Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1995. http://hdl.handle.net/11427/22056en_ZA
dc.identifier.citationShabalala, I. 1995. Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Shabalala, Innocent Philani AB - Pseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG) and Differential Scanning Calorimetry (DSC) were used to investigate such thermal properties of the crystals as stabilities, desolvation processes and their kinetics as well as the melting of pure polymorphic forms of the drugs resulting from desolvation. Complementary studies of the compounds using X-ray powder diffraction (XRD) and DSC allowed identification and assignment of the products of desolvation i.e. polymorphs. Single crystal studies were carried out by X-ray diffraction methods. Interesting structural features such as crystal packing modes, hydrogen bonding schemes, cavity versus channel occupation by guest molecules and host conformations were investigated. From a high level of agreement of results obtained using these methods, the pseudopolymorphs and polymorphs studied were characterized unambiguously. DA - 1995 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1995 T1 - Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs TI - Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs UR - http://hdl.handle.net/11427/22056 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22056
dc.identifier.vancouvercitationShabalala IP. Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1995 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22056en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleStructures and thermal decompositions of pseudopolymorphs of sulfonamide drugsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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