Asking the right questions: developing evidence-based strategies for treating HIV in women and children

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dc.contributor.authorKarim, Quarraishaen_ZA
dc.contributor.authorBanegura, Anchillaen_ZA
dc.contributor.authorCahn, Pedroen_ZA
dc.contributor.authorChristie, Celiaen_ZA
dc.contributor.authorDintruff, Roberten_ZA
dc.contributor.authorDistel, Manuelen_ZA
dc.contributor.authorHankins, Catherineen_ZA
dc.contributor.authorHellmann, Nicholasen_ZA
dc.contributor.authorKatabira, Ellyen_ZA
dc.contributor.authorLehrman, Sandraen_ZA
dc.contributor.authorMontaner, Julioen_ZA
dc.contributor.authorPurdon, Scotten_ZA
dc.contributor.authorRooney, Jamesen_ZA
dc.contributor.authorWood, Robinen_ZA
dc.contributor.authorHeidari, Shirien_ZA
dc.date.accessioned2015-11-04T11:46:48Z
dc.date.available2015-11-04T11:46:48Z
dc.date.issued2011en_ZA
dc.description.abstractIn July 2010, the World Health Organization (WHO) issued formal revisions of its guidelines on the use of highly active antiretroviral therapy for HIV. The new guidelines greatly expand eligibility for treatment of adults and children, as well as for pregnant women seeking prophylaxis for vertical HIV transmission. WHO's new recommendations bring the guidelines closer to practices in developed countries, and its shift to earlier treatment alone will increase the number of treatment-eligible people by 50% or more.Scaling up access to HIV treatment is revealing important gaps in our understanding of how best to provide for all those in need. This knowledge gap is especially significant in developing countries, where women and children comprise a majority of those living with HIV infection. Given the magnitude and significance of these populations, the International AIDS Society, through its Industry Liaison Forum, prioritized HIV treatment and prophylaxis of women and children. In March 2010, the International AIDS Society and 15 partners launched a Consensus Statement outlining priority areas in which a relative lack of knowledge impedes delivery of optimal prevention of mother to child transmission (PMTCT) and treatment to women and children.The Consensus Statement, "Asking the Right Questions: Advancing an HIV Research Agenda for Women and Children", makes a special appeal for a more gender-sensitive approach to HIV research at all stages, from conception to design and implementation. It particularly emphasizes research to enhance the understanding of sex-based differences and paediatric needs in treatment uptake and response. In addition to clinical issues, the statement focuses on programmatic research that facilitates access and adherence to antiretroviral regimens. Better coordination of HIV management with sexual and reproductive healthcare delivery is one such approach.We discuss here our knowledge gaps concerning effective, safe PMTCT and treatment for women and children in light of the expansion envisioned by WHO's revised guidelines. The guideline's new goals present an opportunity for advancing the women and children's agenda outlined in the Consensus Statement.en_ZA
dc.identifier.apacitationKarim, Q., Banegura, A., Cahn, P., Christie, C., Dintruff, R., Distel, M., ... Heidari, S. (2011). Asking the right questions: developing evidence-based strategies for treating HIV in women and children. <i>BMC Public Health</i>, http://hdl.handle.net/11427/14663en_ZA
dc.identifier.chicagocitationKarim, Quarraisha, Anchilla Banegura, Pedro Cahn, Celia Christie, Robert Dintruff, Manuel Distel, Catherine Hankins, et al "Asking the right questions: developing evidence-based strategies for treating HIV in women and children." <i>BMC Public Health</i> (2011) http://hdl.handle.net/11427/14663en_ZA
dc.identifier.citationKarim, Q. A., Banegura, A., Cahn, P., Christie, C. D., Dintruff, R., Distel, M., ... & Heidari, S. (2011). Asking the right questions: developing evidence-based strategies for treating HIV in women and children. BMC public health, 11(1), 388.en_ZA
dc.identifier.ris TY - Journal Article AU - Karim, Quarraisha AU - Banegura, Anchilla AU - Cahn, Pedro AU - Christie, Celia AU - Dintruff, Robert AU - Distel, Manuel AU - Hankins, Catherine AU - Hellmann, Nicholas AU - Katabira, Elly AU - Lehrman, Sandra AU - Montaner, Julio AU - Purdon, Scott AU - Rooney, James AU - Wood, Robin AU - Heidari, Shiri AB - In July 2010, the World Health Organization (WHO) issued formal revisions of its guidelines on the use of highly active antiretroviral therapy for HIV. The new guidelines greatly expand eligibility for treatment of adults and children, as well as for pregnant women seeking prophylaxis for vertical HIV transmission. WHO's new recommendations bring the guidelines closer to practices in developed countries, and its shift to earlier treatment alone will increase the number of treatment-eligible people by 50% or more.Scaling up access to HIV treatment is revealing important gaps in our understanding of how best to provide for all those in need. This knowledge gap is especially significant in developing countries, where women and children comprise a majority of those living with HIV infection. Given the magnitude and significance of these populations, the International AIDS Society, through its Industry Liaison Forum, prioritized HIV treatment and prophylaxis of women and children. In March 2010, the International AIDS Society and 15 partners launched a Consensus Statement outlining priority areas in which a relative lack of knowledge impedes delivery of optimal prevention of mother to child transmission (PMTCT) and treatment to women and children.The Consensus Statement, "Asking the Right Questions: Advancing an HIV Research Agenda for Women and Children", makes a special appeal for a more gender-sensitive approach to HIV research at all stages, from conception to design and implementation. It particularly emphasizes research to enhance the understanding of sex-based differences and paediatric needs in treatment uptake and response. In addition to clinical issues, the statement focuses on programmatic research that facilitates access and adherence to antiretroviral regimens. Better coordination of HIV management with sexual and reproductive healthcare delivery is one such approach.We discuss here our knowledge gaps concerning effective, safe PMTCT and treatment for women and children in light of the expansion envisioned by WHO's revised guidelines. The guideline's new goals present an opportunity for advancing the women and children's agenda outlined in the Consensus Statement. DA - 2011 DB - OpenUCT DO - 10.1186/1471-2458-11-388 DP - University of Cape Town J1 - BMC Public Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Asking the right questions: developing evidence-based strategies for treating HIV in women and children TI - Asking the right questions: developing evidence-based strategies for treating HIV in women and children UR - http://hdl.handle.net/11427/14663 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14663
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2458-11-388
dc.identifier.vancouvercitationKarim Q, Banegura A, Cahn P, Christie C, Dintruff R, Distel M, et al. Asking the right questions: developing evidence-based strategies for treating HIV in women and children. BMC Public Health. 2011; http://hdl.handle.net/11427/14663.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Karim et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Public Healthen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcpublichealth/en_ZA
dc.subject.otherAntiretroviral Therapyen_ZA
dc.subject.otherEvidence-Based Medicineen_ZA
dc.titleAsking the right questions: developing evidence-based strategies for treating HIV in women and childrenen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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