High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa

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dc.contributor.authorSchaftenaar, Eriken_ZA
dc.contributor.authorVerjans, Georges M G Men_ZA
dc.contributor.authorGetu, Sarahen_ZA
dc.contributor.authorMcIntyre, James Aen_ZA
dc.contributor.authorStruthers, Helen Een_ZA
dc.contributor.authorOsterhaus, Albert D M Een_ZA
dc.contributor.authorPeters, Remco P Hen_ZA
dc.date.accessioned2016-01-11T06:57:33Z
dc.date.available2016-01-11T06:57:33Z
dc.date.issued2014en_ZA
dc.description.abstractSeroprevalence data of human herpesviruses (HHVs) are limited for sub-Saharan Africa. These are important to provide an indication of potential burden of HHV-related disease, in particular in human immunodeficiency virus (HIV)-infected individuals who are known to be at increased risk of these conditions in the Western world. In this cross-sectional study among 405 HIV-infected and antiretroviral therapy naïve individuals in rural South Africa the seroprevalence of HHVs was: herpes simplex virus type 1 (HSV-1) (98%), herpes simplex virus type 2 (HSV-2) (87%), varicella zoster virus (VZV) (89%), and 100% for both Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Independent factors associated with VZV seropositivity were low educational status and having children. Lack of in-house access to drinking water was independently associated with positive HSV-1 serostatus, whereas Shangaan ethnicity was associated with HSV-2 seropositivity. Increasing age was associated with higher IgG titres to both EBV and CMV, whereas CD4 cell count was negatively associated with EBV and CMV IgG titres. Moreover, IgG titres of HSV-1 and 2, VZV and CMV, and CMV and EBV were positively correlated. The high HHV seroprevalence emphasises the importance of awareness of these viral infections in HIV-infected individuals in South Africa.en_ZA
dc.identifier.apacitationSchaftenaar, E., Verjans, G. M. G. M., Getu, S., McIntyre, J. A., Struthers, H. E., Osterhaus, A. D. M. E., & Peters, R. P. H. (2014). High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16324en_ZA
dc.identifier.chicagocitationSchaftenaar, Erik, Georges M G M Verjans, Sarah Getu, James A McIntyre, Helen E Struthers, Albert D M E Osterhaus, and Remco P H Peters "High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/16324en_ZA
dc.identifier.citationSchaftenaar, E., Verjans, G. M., Getu, S., McIntyre, J. A., Struthers, H. E., Osterhaus, A. D., & Peters, R. P. (2013). High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa. PloS one, 9(6), e99243. doi:10.1371/journal.pone.0099243en_ZA
dc.identifier.ris TY - Journal Article AU - Schaftenaar, Erik AU - Verjans, Georges M G M AU - Getu, Sarah AU - McIntyre, James A AU - Struthers, Helen E AU - Osterhaus, Albert D M E AU - Peters, Remco P H AB - Seroprevalence data of human herpesviruses (HHVs) are limited for sub-Saharan Africa. These are important to provide an indication of potential burden of HHV-related disease, in particular in human immunodeficiency virus (HIV)-infected individuals who are known to be at increased risk of these conditions in the Western world. In this cross-sectional study among 405 HIV-infected and antiretroviral therapy naïve individuals in rural South Africa the seroprevalence of HHVs was: herpes simplex virus type 1 (HSV-1) (98%), herpes simplex virus type 2 (HSV-2) (87%), varicella zoster virus (VZV) (89%), and 100% for both Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Independent factors associated with VZV seropositivity were low educational status and having children. Lack of in-house access to drinking water was independently associated with positive HSV-1 serostatus, whereas Shangaan ethnicity was associated with HSV-2 seropositivity. Increasing age was associated with higher IgG titres to both EBV and CMV, whereas CD4 cell count was negatively associated with EBV and CMV IgG titres. Moreover, IgG titres of HSV-1 and 2, VZV and CMV, and CMV and EBV were positively correlated. The high HHV seroprevalence emphasises the importance of awareness of these viral infections in HIV-infected individuals in South Africa. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0099243 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa TI - High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa UR - http://hdl.handle.net/11427/16324 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16324
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0099243
dc.identifier.vancouvercitationSchaftenaar E, Verjans GMGM, Getu S, McIntyre JA, Struthers HE, Osterhaus ADME, et al. High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa. PLoS One. 2014; http://hdl.handle.net/11427/16324.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2014 Schaftenaar et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHuman cytomegalovirusen_ZA
dc.subject.otherEpstein-Barr virusen_ZA
dc.subject.otherHerpes simplex virus-1en_ZA
dc.subject.otherHerpes simplex virus-2en_ZA
dc.subject.otherEthnic epidemiologyen_ZA
dc.subject.otherHerpes simplex virusen_ZA
dc.subject.otherAdultsen_ZA
dc.subject.otherHIVen_ZA
dc.titleHigh seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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