Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study

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dc.contributor.authorRamma, Lebogangen_ZA
dc.contributor.authorIbekwe, Titusen_ZA
dc.date.accessioned2015-11-18T03:58:04Z
dc.date.available2015-11-18T03:58:04Z
dc.date.issued2012en_ZA
dc.description.abstractABSTRACTS:BACKGROUND: To investigate the Cochleo-vestibular clinical and audiometric findings in Multi and Extreme Drug Resistance(MDR and XDR) tuberculosis(TB) patients on treatment and make recommendations. METHODS: A cross-sectional study of adult MDR and XDR-TB patients was conducted in a general hospital in Cape-Town-South-Africa. Ethical approval was secured and all consenting patients administered with pretested and validated questionnaire under the guidance of International Classification of Functioning, Disability and Health(ICF) Checklist-version-2.1a. Audiometric evaluation included: Otoscopy, Diagnostic Audiometry and Tympanometry. The data analyses were done with SPSS version 16, Chi-square and StatCalc-7. RESULTS: Fifty-three adults, ages 18-60 (mean-33 years) comprising 26 males and 27 females participated in the study. Hospital stay duration varied from 1-18 months (mean-6 months) and all were on anti-Koch's second line drugs (regimen 2). MDR TB group were 45(85%) and XDR 8(15%). Vertigo was the most common vestibular symptoms, 24(45%) whereas, tinnitus 23(42%) and hearing loss 13(25%) were most frequent auditory complaints. Bilateral sensorineural hearing losses of varying degrees were confirmed in 23(47%).There was no association between gender and age with hearing loss [chi2 (P = 0.16, alpha = 0.05) and (p = 0.13, alpha = 0.05)]. Furthermore, MDR and XTR TB groups [20/42 Vs 3/8; Z = 0.46 and P = 0.64], showed no difference in pattern of the hearing losses. CONCLUSIONS: A multi-disciplinary close surveillance of MDR and XDR TB patients on therapy is imperative. Finally, researches into therapeutic trials on antidotes and potent safer substitutes for aminoglycosides in the management are recommended.en_ZA
dc.identifier.apacitationRamma, L., & Ibekwe, T. (2012). Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study. <i>International Archives of Medicine</i>, http://hdl.handle.net/11427/15073en_ZA
dc.identifier.chicagocitationRamma, Lebogang, and Titus Ibekwe "Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study." <i>International Archives of Medicine</i> (2012) http://hdl.handle.net/11427/15073en_ZA
dc.identifier.citationRamma, L., & Ibekwe, T. S. (2012). Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study. International archives of medicine, 5(1), 3.en_ZA
dc.identifier.ris TY - Journal Article AU - Ramma, Lebogang AU - Ibekwe, Titus AB - ABSTRACTS:BACKGROUND: To investigate the Cochleo-vestibular clinical and audiometric findings in Multi and Extreme Drug Resistance(MDR and XDR) tuberculosis(TB) patients on treatment and make recommendations. METHODS: A cross-sectional study of adult MDR and XDR-TB patients was conducted in a general hospital in Cape-Town-South-Africa. Ethical approval was secured and all consenting patients administered with pretested and validated questionnaire under the guidance of International Classification of Functioning, Disability and Health(ICF) Checklist-version-2.1a. Audiometric evaluation included: Otoscopy, Diagnostic Audiometry and Tympanometry. The data analyses were done with SPSS version 16, Chi-square and StatCalc-7. RESULTS: Fifty-three adults, ages 18-60 (mean-33 years) comprising 26 males and 27 females participated in the study. Hospital stay duration varied from 1-18 months (mean-6 months) and all were on anti-Koch's second line drugs (regimen 2). MDR TB group were 45(85%) and XDR 8(15%). Vertigo was the most common vestibular symptoms, 24(45%) whereas, tinnitus 23(42%) and hearing loss 13(25%) were most frequent auditory complaints. Bilateral sensorineural hearing losses of varying degrees were confirmed in 23(47%).There was no association between gender and age with hearing loss [chi2 (P = 0.16, alpha = 0.05) and (p = 0.13, alpha = 0.05)]. Furthermore, MDR and XTR TB groups [20/42 Vs 3/8; Z = 0.46 and P = 0.64], showed no difference in pattern of the hearing losses. CONCLUSIONS: A multi-disciplinary close surveillance of MDR and XDR TB patients on therapy is imperative. Finally, researches into therapeutic trials on antidotes and potent safer substitutes for aminoglycosides in the management are recommended. DA - 2012 DB - OpenUCT DO - 10.1186/1755-7682-5-3 DP - University of Cape Town J1 - International Archives of Medicine LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study TI - Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study UR - http://hdl.handle.net/11427/15073 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15073
dc.identifier.urihttp://dx.doi.org/10.1186/1755-7682-5-3
dc.identifier.vancouvercitationRamma L, Ibekwe T. Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study. International Archives of Medicine. 2012; http://hdl.handle.net/11427/15073.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Communication Sciences and Disordersen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Ramma and Ibekwe; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceInternational Archives of Medicineen_ZA
dc.source.urihttp://archive.biomedcentral.com/1755-7682/en_ZA
dc.subject.otherMultidrug resistanceen_ZA
dc.subject.otherExtreme drug resistanceen_ZA
dc.subject.otherAminoglycosidesen_ZA
dc.subject.otherototoxicityen_ZA
dc.titleCochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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