The total synthesis of aristolindiquinone

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dc.contributor.advisorGiles, Robin G Fen_ZA
dc.contributor.authorBotha, Marc Edgaren_ZA
dc.date.accessioned2016-10-14T06:27:15Z
dc.date.available2016-10-14T06:27:15Z
dc.date.issued1986en_ZA
dc.descriptionBibliography: pages 97-99.en_ZA
dc.description.abstractAristolindiquinone (1), a novel natural compound possibly: possessing anti-fertility activity, was synthesized via two independent routes. First, a Stobbe reaction unambiguously gave the naphthalene nucleus with the required substitution pattern (3,8-dioxygenated-2,5-dimethyl naphthalene), starting from 2-hydroxy-5-methylbenzaldehyde (31). Second, a general synthesis, of substituted C-5 oxygenated- 1,4-naphthoquinones is applied to the synthesis of (1). The critical step in the synthesis is the reaction of the novel Diels-Alder partners, dienophile (90), synthesized from 2,6-dihydroxytoluene (56), and diene (109).en_ZA
dc.identifier.apacitationBotha, M. E. (1986). <i>The total synthesis of aristolindiquinone</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/22134en_ZA
dc.identifier.chicagocitationBotha, Marc Edgar. <i>"The total synthesis of aristolindiquinone."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1986. http://hdl.handle.net/11427/22134en_ZA
dc.identifier.citationBotha, M. 1986. The total synthesis of aristolindiquinone. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Botha, Marc Edgar AB - Aristolindiquinone (1), a novel natural compound possibly: possessing anti-fertility activity, was synthesized via two independent routes. First, a Stobbe reaction unambiguously gave the naphthalene nucleus with the required substitution pattern (3,8-dioxygenated-2,5-dimethyl naphthalene), starting from 2-hydroxy-5-methylbenzaldehyde (31). Second, a general synthesis, of substituted C-5 oxygenated- 1,4-naphthoquinones is applied to the synthesis of (1). The critical step in the synthesis is the reaction of the novel Diels-Alder partners, dienophile (90), synthesized from 2,6-dihydroxytoluene (56), and diene (109). DA - 1986 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1986 T1 - The total synthesis of aristolindiquinone TI - The total synthesis of aristolindiquinone UR - http://hdl.handle.net/11427/22134 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22134
dc.identifier.vancouvercitationBotha ME. The total synthesis of aristolindiquinone. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1986 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22134en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleThe total synthesis of aristolindiquinoneen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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